PMID: 8591707Sep 1, 1995Paper

Renoprotective effect of enalapril in uninephrectomized spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes

Diabetes Research and Clinical Practice
Y SatoM Fujishima

Abstract

We compared the renoprotective effect between angiotensin-converting enzyme inhibitor, enalapril, and a dihydropyridine-type calcium channel blocker, nicardipine, in a severe form of renal injury in rats. Two-day-old spontaneously hypertensive rats (SHR) were injected with streptozotocin or vehicle as control. UNX was performed at 3 weeks of age, and enalapril or nicardipine was administered in drinking water from 7 weeks of age. Uninephrectomy (UNX) markedly exacerbated hypertension and renal injury in the nondiabetic and diabetic SHR. Enalapril and nicardipine comparably reduced blood pressure in UNX diabetic SHR. However, serum creatinine was significantly elevated in the nicardipine-treated group as compared with the enalapril-treated group at 24 weeks of age (nicardipine-treated group, 67 +/- 4 microM; enalapril-treated group, 49 +/- 3 microM; P < 0.01; untreated group 57 +/- 4 microM). Furthermore, the incidence of glomerular sclerosis was similar between untreated and nicardipine-treated groups, whereas it tended to be reduced in the enalapril-treated group. In a separate experiment of diabetic SHR without UNX, enalapril therapy significantly ameliorated hyperglycemia and albuminuria (P < 0.01). This study showed that a ...Continue Reading

References

Oct 1, 1992·Journal of the American Society of Nephrology : JASN·S Anderson
Apr 1, 1992·Kidney International·S AndersonB M Brenner
Dec 1, 1989·Kidney International·F P BrunnerM J Mihatsch
Oct 1, 1993·Diabetes Care
May 1, 1993·Diabetes Care·S M Haffner
Sep 12, 2001·Current Hypertension Reports·J G Umans, M D Lindheimer

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Citations

Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Yufeng HuangNancy A Noble
Sep 1, 2009·Biochemical and Biophysical Research Communications·Homare ShimohataSatoru Takahashi
Mar 31, 2012·International Journal of Experimental Pathology·Azadeh KhaliliShima Fakher
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·V D NenovB M Brenner

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