Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
ChaoYue SunBing Feng

Abstract

Cisplatin remains the standard first-line chemotherapeutic agent in the treatment of many types of cancers, but its clinical application is hindered by its severe nephrotoxicity. Previous studies reported that scutellarin enhanced the anti-cancer activity of cisplatin in lung cancer cells, with no confirmation on cisplatin-induced renal damage. Here, we investigated the nephroprotective effect of scutellarin on cisplatin-induced renal injury and its underlying mechanisms. Renal function, histological change, inflammation, apoptosis, autophagy and involved pathways were investigated. Pretreatment with scutellarin prevented cisplatin-induced decline of renal function including BUN, CRE, and histological damage. Scutellarin also reduced renal inflammation by suppressing the levels of pro-inflammatory cytokine, TNF-α and IL-6. Similarly, scutellarin administration inhibited apoptosis triggered by cisplatin through reducing the expressions of Cleaved caspase-3, Cleaved PARP, p53, and the ratio of Bax/Bcl-2. Moreover, scutellarin prevented cisplatin-induced inhibition of autophagy via enhancing LC3-II/LC3-I and Atg7, and inhibition of p62. Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenu...Continue Reading

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Citations

Jun 23, 2019·International Journal of Molecular Sciences·Sara J HolditchCharles L Edelstein
Jun 17, 2020·Archives of Physiology and Biochemistry·Tiss MohamedKhaled Hamden
Mar 3, 2021·The International Journal of Neuroscience·Filiz KazakMehmet Zeki Yılmaz Deveci
Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng
May 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen GaoZhihui Hao
Jun 7, 2021·Journal of Applied Toxicology : JAT·Yan-Ping LiuZhao-Hui Zhang
Jun 3, 2021·Pharmaceuticals·Pía LorenLuis A Salazar
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Dan XuGang Shu
Jun 30, 2021·Pharmaceutical Development and Technology·Mingxi MaFei Xiong

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