Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1.

International Urology and Nephrology
Fatemeh Darvishzadeh MahaniAlireza Raji-Amirhasani

Abstract

Acute kidney injury (AKI) is a common syndrome associated with high morbidity and mortality, despite progress in medical care. Many studies have shown that there are sex differences and different role of sex hormones particularly estrogens in kidney injury. In this regard, the incidence and rate of progression of kidney diseases are higher in men compared with women. These observations suggest that female sex hormone may be renoprotective. Silent information regulator 2 homolog 1 (SIRT1) is a histone deacetylase, which is implicated in multiple biologic processes in several organisms. In the kidneys, SIRT1 inhibits renal cell apoptosis, inflammation, and fibrosis. Studies have reported a link between SIRT1 and estrogen. In addition, SIRT1 regulates ERα expression and inhibition of SIRT1 activity suppresses ERα expression. This effect leads to inhibition of estrogen-responsive gene expression. In this text, we review the role of SIRT1 in mediating the protective effects of estrogen in the onset and progression of AKI.

References

Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J KaufmanR Hamburger
May 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J L HolleyM Schiff
Feb 14, 1998·Kidney International·R C Blantz
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·Joel NeugartenSharon R Silbiger
Aug 5, 2000·American Journal of Physiology. Renal Physiology·J NeugartenS Silbiger
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Mylene PotierMichael Karl
Oct 24, 2001·Cell·H VaziriR A Weinberg
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin NashSusan Hou
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Joel Neugarten
Mar 5, 2003·Advances in Renal Replacement Therapy·Sharon R Silbiger, Joel Neugarten
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Camilla Birch NielsenKlaus Thomsen
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Marie-Luise GrossEberhard Ritz
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Aug 18, 2004·Biochemical Pharmacology·Raphaël MargueronVincent Cavaillès
Sep 11, 2004·The Journal of Biological Chemistry·Kwon Moo ParkJoseph V Bonventre
Sep 30, 2004·American Journal of Physiology. Renal Physiology·Richard W MankheyChristine Maric
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephanie A DeanFrans H H Leenen
Dec 1, 2004·Kidney International·Joel BlushJoel Neugarten
Mar 1, 2005·Cell·Leonard Guarente, Frédéric Picard
Mar 19, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nobuko MatsushitaMinoru Takata
Mar 2, 2006·Molecular Interventions·Dipak K Das, Nilanjana Maulik
Apr 14, 2006·Current Medicinal Chemistry·Nazar LabinskyyZoltan Ungvari
Jun 7, 2006·The Journal of Urology·Peter D Metcalfe, Kirstan K Meldrum
Aug 26, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard W MankheyChristine Maric
Sep 7, 2006·Journal of Cardiovascular Pharmacology·Gyorgyi StefGabor Veress
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Xiang-Qun DengNing-Xu Li
May 18, 2007·Kidney International·C-Y HsuA S Go
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ilwola MattagajasinghKaikobad Irani
Sep 20, 2007·Aging Cell·Laura BordoneLeonard Guarente
Oct 16, 2007·Molecular Cell·Xiaoling LiLeonard Guarente
Dec 13, 2007·American Journal of Physiology. Endocrinology and Metabolism·Peter D MetcalfeKirstan K Meldrum
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·In Hye LeeToren Finkel
Apr 11, 2008·Critical Care Medicine·Eric A J Hoste, Marie Schurgers
May 28, 2008·Gender Medicine·Christine Maric, Shannon Sullivan

❮ Previous
Next ❯

Citations

Jul 6, 2021·Frontiers in Pharmacology·Xun ZhouNa Liu
Nov 11, 2021·Canadian Journal of Physiology and Pharmacology·Samin NahavandiAghdas Dehghani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Sheng li ke xue jin zhan [Progress in physiology]
Rong CaoJi-Hong Kang
Médecine sciences : M/S
Fabienne GuillaumondMichèle Teboul
Circulation Research
Daniel Sedding, Judith Haendeler
Biotechnology Journal
Walter StünkelJeanette Wood
© 2021 Meta ULC. All rights reserved