Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats

American Journal of Physiology. Renal Physiology
Jeong Woo ParkSoo Wan Kim

Abstract

Vitamin D is thought to exert a protective effect on renal disease progression, but the underlying molecular mechanism remains unclear. We investigated whether paricalcitol ameliorates tubular dysfunction and fibrosis in gentamicin (GM)-induced renal injury. Two groups of rats were treated with GM (100 mg x kg(-1) x day(-1)), one of which was cotreated with paricalcitol (0.3 microg x kg(-1) x day(-1)) for 14 days and the other was not. The control group was treated with vehicle only. HK-2 cells were cultured with GM in the absence or presence of paricalcitol. Paricalcitol restored impaired renal function and the downregulated renal sodium transporters and aquaporin-1 expression caused by GM. ED-1-expressing monocyte/macrophage accumulation induced by GM was attenuated by paricalcitol treatment. Paricalcitol prevented upregulated inflammatory cytokines (TNF-alpha, IL-1beta, INF-gamma) and adhesion molecules (monocyte chemoattractant protein-1, ICAM-1, VCAM-1) induced by GM. In addition, paricalcitol effectively reversed TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) process and extracellular matrix accumulation in GM-induced nephropathy. Increased collagen deposition and fibrosis in GM-treated kidney were ameliorat...Continue Reading

References

Sep 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T WeinreichE Ritz
Sep 1, 1995·The Journal of Clinical Investigation·S K MoestrupE I Christensen
Aug 13, 1999·The American Journal of Physiology·A J BrownE Slatopolsky
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Feb 13, 2001·Kidney International·C Guijarro, J Egido
May 5, 2001·The American Journal of Pathology·K MakibayashiT Doi
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J ZavadilE P Bottinger
Jun 26, 2001·Kidney International·V PanichiG Camussi
Jul 18, 2001·American Journal of Physiology. Renal Physiology·J NagaiM Takano
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 15, 2002·European Journal of Pharmacology·Salvatore CuzzocreaDaniela Salvemini
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Erwin P Böttinger, Markus Bitzer
Sep 25, 2002·Biochemical and Biophysical Research Communications·Nianzeng XingMatthew D Griffin
Feb 7, 2003·Pharmacology·George AlexandridisMoses Elisaf
Mar 13, 2003·Kidney International·Takao MasakiDavid J Nikolic-Paterson
Jul 31, 2003·Journal of Pineal Research·Hakan ParlakpinarAhmet Acet
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Alexander KuhlmannKerstin Amann
Apr 3, 2004·Molecular and Cellular Biology·Kevin W Trotter, Trevor K Archer
Jun 12, 2004·Journal of Biomolecular Screening·Christopher RosenauM Walid Qoronfleh
May 25, 2006·Contributions to Nephrology·Wai-Kei Lo
Nov 4, 2006·Journal of the American Society of Nephrology : JASN·Xiaoyue TanYouhua Liu
Jan 9, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoyue TanYouhua Liu
Feb 23, 2007·Journal of the American Society of Nephrology : JASN·Christoph SchmidtMichael Bucher
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Gemma FeldmanMichael P Ryan
May 22, 2007·Journal of the American Society of Nephrology : JASN·Masahide MizobuchiEduardo Slatopolsky
Jun 6, 2008·Journal of the American Society of Nephrology : JASN·Xiaoyue TanYouhua Liu
Jul 25, 2008·Kidney International·Detlef O Schlondorff
Feb 6, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emma T B OlesenSøren Nielsen

❮ Previous
Next ❯

Citations

Apr 10, 2013·European Journal of Pharmacology·Vanessa PérezRamón Romero
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyeon Seok HwangChul Woo Yang
Dec 7, 2011·Current Opinion in Nephrology and Hypertension·Yan C Li
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Qin-Qin LinKai-Fan Zhang
Jan 18, 2014·Biochemical and Biophysical Research Communications·Jae-Won LeeHyoung Kyu Kim
Jul 17, 2014·American Journal of Respiratory and Critical Care Medicine·David E LeafSushrut S Waikar
Jul 18, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Laura M G MeemsRudolf A de Boer
Sep 24, 2010·Kidney International·Jose M Lopez-NovoaFrancisco J Lopez-Hernandez
Mar 28, 2012·European Journal of Pharmacology·Jeong Woo ParkSoo Wan Kim
Dec 19, 2012·Cellular Immunology·Lina YangLining Wang
Mar 20, 2014·Clinical and Experimental Nephrology·Sang Heon SuhSoo Wan Kim
Dec 17, 2014·Seminars in Nephrology·D J A GoldsmithV Brandenburg
Sep 8, 2016·Journal of Cellular and Molecular Medicine·Jonay PovedaMaria D Sanchez-Niño
Jun 26, 2013·Antimicrobial Agents and Chemotherapy·Mohammad A K AzadJian Li
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Heon SuhSoo Wan Kim
Oct 26, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiyeon KoDuk-Hee Kang
Jul 22, 2014·The Korean Journal of Internal Medicine·Chang Seong Kim, Soo Wan Kim
Aug 26, 2019·Biological Trace Element Research·Sinan InceNuray Varol
May 10, 2020·Clinical and Experimental Pharmacology & Physiology·Zeinab KarimiSahar Janfeshan
Apr 3, 2020·International Journal of Molecular Sciences·Chi-Cheng LaiPei-Wen Cheng
Feb 28, 2019·BioMed Research International·Yu FuJuan Kong
Oct 24, 2014·American Journal of Physiology. Renal Physiology·Michelle M DuffyMatthew D Griffin
Dec 13, 2016·Clinical and Experimental Nephrology·Takayuki HamanoYoshitaka Isaka
Jul 4, 2018·Clinical and Experimental Nephrology·Magda HamzawyNivin Sharawy
May 24, 2013·American Journal of Physiology. Renal Physiology·Indira D PokkunuriMohammad Asghar
Mar 10, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Hui BaeSoo Wan Kim
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Eunjin BaeDong Jun Park
Dec 5, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yiyou LinChangyu Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

© 2022 Meta ULC. All rights reserved