Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes

Journal of Diabetes Research
Cristina MegaFlávio Reis

Abstract

Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients. It is also acknowledged as an independent risk factor for cardiovascular disease (CVD). Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties. Despite overall recommendations, many patients spend a long time well outside the recommended glycaemic range and, therefore, have an increased risk for developing micro- and macrovascular complications. Currently, it is becoming clearer that type 2 diabetes mellitus (T2DM) management must envision not only the improvement in glycaemic control but also, and particularly, the prevention of pancreatic deterioration and the evolution of complications, such as DN. This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemo...Continue Reading

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Citations

Aug 28, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Mar 12, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shiva BorzoueiMahdi Alahgholi-Hajibehzad
Jun 30, 2018·Clinical Science·Josselin Nespoux, Volker Vallon
Nov 14, 2018·BioMed Research International·Chenyang ZhaoYang Luo
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Małgorzata TrochaTomasz Sozański
Oct 31, 2020·Journal of Diabetes Research·Eleftheria PapachristoforouKonstantinos Makrilakis
Nov 5, 2021·Fundamental & Clinical Pharmacology·Reham Hussein MohamedSherin Shafik Tawfik

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