PMID: 43714Nov 1, 1979

Renovascular hypertension and beta blockers. Theoretical and practical implications

Archives des maladies du coeur et des vaisseaux
J GuédonM Chaignon

Abstract

Beta blockade was instituted in 10 patients with renovascular hypertension due to renal artery stenosis or thrombosis. The treatment was very effective in unilateral stenosis with a normal contralateral kidney (2 kidney Goldblatt) and in fibromuscular dystrophy of the renal artery. On the other hand many failures were observed in hypertension with a single kidney (1 kidney Goldblatt) and in renovascular hypertension with complex lesions or associated renal failure. Although a clear relationship was often observed between the increased plasma renin activity and the antihypertensive effect of beta blockade, this association was sometimes completely erroneous. Beta blockade, which is easy to perform, should be tried out systematically in renovascular hypertension, but, when no result is observed, this therapeutic test should not exclude surgical management thereafter.

Related Concepts

Adrenergic beta-Antagonists
Antihypertensive Agents
Fibromuscular Dysplasia
Renal Hypertension
Hypertension, Renovascular
Renal Artery Stenosis
Preprorenin
Thrombus

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