Renovascular hypertension due to antithrombin deficiency in childhood

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Kaori MiuraGoro Takada

Abstract

Inherited antithrombin deficiency generally causes a predisposition toward vascular thrombus above the age of 15 years. A 1-year-old boy developed renal hypertension caused by renal artery obstruction due to thrombus formation. This thrombus formation was attributed to antithrombin deficiency caused by a novel SERPINCI gene mutation (AT III Akita, M352R). This suggests that antithrombin deficiency can cause renal artery obstruction, inducing renal hypertension through vascular thrombosis even in children.

References

Jan 1, 1986·Clinical and Laboratory Haematology·R CandrinaG Giustina
Feb 26, 1982·JAMA : the Journal of the American Medical Association·J H WinterA S Douglas
May 1, 1981·JAMA : the Journal of the American Medical Association·M E ShapiroE W Salzman

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