PMID: 8613601Mar 15, 1996Paper

Reocclusion: the flip side of coronary thrombolysis

Journal of the American College of Cardiology
F W VerheugtM J van Eenige

Abstract

Since the introduction of thrombolytic therapy for acute myocardial infarction, the incidence of coronary artery reocclusion has been intensively studied. Also, the prediction and diagnosis of reocclusion by angiographic and clinical variables, as well its invasive and pharmacologic prevention, have gained much attention. By angiographic definition, reocclusion requires three angiographic observations: one with an occluded artery, one with a reperfused artery and a third for the assessment of subsequent occlusion (true reocclusion). Since the introduction of early intravenous reperfusion therapy, most studies use only two angiograms: one with a patent and one with a nonpatent infarct-related artery. A search for all published reocclusion studies revealed 61 studies (6,061 patients) with at least two angiograms. The median time interval between the first angiogram after thrombolysis and the second was 16 days (range 0.1 to 365). Reocclusion was observed in 666 (11%) of 6,061 cases. Interestingly, the 28 true reocclusion studies showed an incidence of reocclusion of 16 +/- 10% (mean +/- SD), and the 33 studies with only two angiograms 10 +/- 8% (p=0.04), suggesting that proven initial occlusion of the infarct-related artery is a ...Continue Reading

References

Mar 1, 1992·Journal of the American College of Cardiology·S RouxE Lüdin
Mar 24, 1990·Lancet·J R O'Brien
Jan 4, 1990·The New England Journal of Medicine·B S Coller
Oct 1, 1989·Journal of the American College of Cardiology·N U BangM D Clayman
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Apr 1, 1986·Journal of the American College of Cardiology·P W SerruysW J Remme
Mar 1, 1987·Journal of the American College of Cardiology·G A Beller
Jan 1, 1986·The American Journal of Cardiology·A K GashR D Gentzler
Apr 1, 1986·Archives of Internal Medicine·G C TimmisJ R Stewart
Jan 1, 1995·Journal of the American College of Cardiology·H D WhiteD B Cross

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Citations

Jun 27, 2008·Journal of Thrombosis and Thrombolysis·Peter C KievitFreek W A Verheugt
Dec 25, 2003·Thrombosis Research·Maryse CourvalChantal Pharand
Oct 31, 2000·International Journal of Cardiology·A QasimR S More
Apr 13, 2001·Journal of the American College of Cardiology·D ScrutinioP Rizzon
Nov 3, 2001·Journal of the American College of Cardiology·J A de Lemos, E Braunwald
Oct 13, 1998·Journal of the American College of Cardiology·S PislaruF Van de Werf
Jun 26, 2009·The New England Journal of Medicine·Freek W A Verheugt
Jan 5, 2002·Expert Opinion on Investigational Drugs·S A Doggrell
Apr 12, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Francisco Fernández-AvilésJosé A San Román
Jun 19, 2012·Thrombosis Research·Alejandro DiegoFelipe Fernandez-Vazquez
Dec 12, 2001·Blood Reviews·V J Marder
Nov 5, 2016·Journal of the American College of Cardiology·Victor Gurewich
Aug 26, 2003·Angiology·On TopazUri Rosenschein
Dec 31, 1997·Circulation·J P Carrozza, D S Baim
Nov 18, 2005·Circulation·Marc S SabatineUNKNOWN Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators
Mar 24, 2010·Current Opinion in Cardiology·Freek W A Verheugt
Jun 5, 1998·The American Journal of Physiology·J A BarrabésJ Soler-Soler
Jul 31, 2019·Computational and Structural Biotechnology Journal·Jan MicanJiri Damborsky

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