Reorganization in the auditory cortex of the rat induced by intracortical microstimulation: a multiple single-unit study

Experimental Brain Research
P E Maldonado, G L Gerstein

Abstract

Many manipulations are able to change or perturb various aspects of single neuron properties and interneuronal relationships. Changes of cerebral cortex organization have been observed in different cortical areas and at different time scales in relation to peripheral stimulation, peripheral damage, associative learning, and electrical stimulation. Here we describe studies on separable multineuron recordings in the rat's auditory cortex under two different anesthetics. Acoustic stimuli were used as a normal, physiological input, and weak electrical intracortical microstimulation (ICMS) as a perturbation that forces a rapid cortical reorganization. ICMS induced fast changes in the cortical map and in the receptive field properties of cells at the electrically stimulated and adjacent electrodes. In effect there was an enlargement of the cortical domain tuned to the acoustic frequency that had been represented at the stimulating electrode. ICMS also incremented afterdischarge responses; these consisted of an initial response to the auditory stimulus followed by less intense repetitive activity that was stimulus-time locked and had a period of 8-12 Hz, similar to that of the spontaneous synchronous activity. Cortical activity under ...Continue Reading

Citations

Sep 17, 2009·Experimental Brain Research·Ralph Leonhardt, Hubert R Dinse
May 10, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Paul H DelanoPedro E Maldonado
May 3, 2000·The European Journal of Neuroscience·C SpielewoyB Giros
Aug 19, 2009·Psychophysiology·Patrick J C May, Hannu Tiitinen
Feb 28, 2002·Current Biology : CB·Jan W H Schnupp, Oliver Kacelnik
Dec 29, 2004·Vision Research·David J Warren, Richard A Normann
Jun 14, 2001·The European Journal of Neuroscience·M A Kisley, G L Gerstein
Jun 2, 2005·Journal of Neural Engineering·Kevin J OttoDaryl R Kipke
Dec 21, 2016·Frontiers in Bioengineering and Biotechnology·Cynthia K OverstreetStephen I Helms Tillery

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