Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder

Neural Plasticity
Jinkun ZengHuaqing Meng

Abstract

Objective. Electroconvulsive therapy (ECT) is considered one of the most effective and fast-acting treatment options for depressive episodes. Little is known, however, about ECT's enabling brain (neuro)plasticity effects, particular for plasticity of white matter pathway. Materials and Methods. We collected longitudinal diffusion tensor imaging in the first-episode, drug-naïve major depressive disorder (MDD) patients (n = 24) before and after a predefined time window ECT treatment. We constructed large-scale anatomical networks derived from white matter fiber tractography and evaluated the topological reorganization using graph theoretical analysis. We also assessed the relationship between topological reorganization with improvements in depressive symptoms. Results. Our investigation revealed three main findings: (1) the small-worldness was persistent after ECT series; (2) anatomical connections changes were found in limbic structure, temporal and frontal lobes, in which the connection changes between amygdala and parahippocampus correlate with depressive symptom reduction; (3) significant nodal strength changes were found in right paralimbic network. Conclusions. ECT elicits neuroplastic processes associated with improvements...Continue Reading

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Citations

Nov 20, 2019·The International Journal of Neuropsychopharmacology·Gregor GryglewskiRupert Lanzenberger
Dec 18, 2020·Frontiers in Psychiatry·Yiming FanLingjiang Li
Apr 6, 2019·Psychiatry Research. Neuroimaging·Preeti SinhaRose Dawn Bharath

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Software Mentioned

Brain Connectivity Toolbox
Pipeline for Analyzing Brain Diffusion Images toolkit ( PANDA

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