PMID: 6400031Oct 1, 1984Paper

Reorganization of contractile elements in the platelet during clot retraction

Journal of Ultrastructure Research
K TanakaN Shibata

Abstract

Electron microscopic studies have been carried out on human platelets in the clot retraction. In the early stage of clot formation, platelets send out filopodia, in which thin filaments run longitudinally. The thin filaments are often observed to attach to the cell membrane where fibrin strands bind from the extracellular surface. In the later stage of clot formation, thick filaments become observable, mainly in the cell body of the platelets. These thick filaments are arranged to form an ordered array, and thin filaments run parallel to them. The thin filaments often attach to the end of the thick filaments. However, thin filaments are not seen between the arrays of thick filaments. Similar structures are also observed in the cytoskeleton of the contracted platelet. These filaments closely resemble the purified myosin aggregates formed under low ionic strength. Thus, during clot retraction, both actin and myosin in platelets are reorganized into thin and thick filaments, respectively.

References

Mar 15, 1975·Experimental Cell Research·N SendaK Tanaka
Oct 1, 1975·The Journal of Cell Biology·R Niederman, T D Pollard
Nov 1, 1971·Journal of Ultrastructure Research·O BehnkeL E Nielsen
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R S AdelsteinW M Kuehl
Feb 1, 1972·The Journal of Clinical Investigation·D Zucker-Franklin, G Grusky
Mar 1, 1972·The Journal of Clinical Investigation·S NiewiarowskiJ F Mustard
Sep 1, 1980·The Journal of Cell Biology·V T Nachmias
Dec 15, 1982·Biochemical and Biophysical Research Communications·T Onji, N Shibata
Feb 1, 1982·The Journal of Cell Biology·R M Leven, V T Nachmias
Feb 1, 1980·The Journal of Clinical Investigation·R M Lyons, J O Shaw
Apr 1, 1981·The Journal of Cell Biology·P A Gonnella, V T Nachmias
Jul 25, 1959·Nature·M BETTEX-GALLAND, E F LUESCHER
Jul 1, 1979·Thrombosis and Haemostasis·Thomas D Pollard
Jul 1, 1979·Thrombosis and Haemostasis·V T NachmiasA Asch

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Citations

Feb 23, 2010·Thrombosis Research·Sun Young Kim, Hye Sook Yun-Choi
Jul 31, 2009·NMR in Biomedicine·Jernej VidmarIgor Sersa
Jan 25, 2003·Blood·Krasimir KolevRaymund Machovich
Dec 1, 1989·Journal of Muscle Research and Cell Motility·S S MargossianH S Slayter
Oct 15, 1985·Biochemical and Biophysical Research Communications·T OnjiN Shibata
Oct 1, 1986·Journal of Ultrastructure and Molecular Structure Research·K TanakaT Onji

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