Reorganization of functional brain network architecture in chronic osteoarthritis pain.

Human Brain Mapping
Joana BarrosoA Vania Apkarian

Abstract

Osteoarthritis (OA) manifests with chronic pain, motor impairment, and proprioceptive changes. However, the role of the brain in the disease is largely unknown. Here, we studied brain networks using the mathematical properties of graphs in a large sample of knee and hip OA (KOA, n = 91; HOA, n = 23) patients. We used a robust validation strategy by subdividing the KOA data into discovery and testing groups and tested the generalizability of our findings in HOA. Despite brain global topological properties being conserved in OA, we show there is a network wide pattern of reorganization that can be captured at the subject-level by a single measure, the hub disruption index. We localized reorganization patterns and uncovered a shift in the hierarchy of network hubs in OA: primary sensory and motor regions and parahippocampal gyrus behave as hubs and insular cortex loses its central placement. At an intermediate level of network structure, frontoparietal and cingulo-opercular modules showed preferential reorganization. We examined the association between network properties and clinical correlates: global disruption indices and isolated degree properties did not reflect clinical parameters; however, by modeling whole brain nodal degr...Continue Reading

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Citations

Apr 28, 2021·Current Opinion in Supportive and Palliative Care·Sabah BhardeShafaq Sikandar
Jun 29, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Joana BarrosoApkar Vania Apkarian
Oct 6, 2021·Journal of Neural Engineering·Zhe Sage Chen
Oct 22, 2021·Frontiers in Neurology·Daniel G WhitneyEdward A Hurvitz

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Software Mentioned

Brain Connectivity Toolbox
MATLAB Brain Connectivity Toolbox
BrainNet Viewer
MATLAB
FMRIB Expert Analysis Tool

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