PMID: 8940302Nov 1, 1996Paper

Reorganization of microfilament structure induced by ac electric fields

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
M R ChoDavid E Golan

Abstract

AC electric fields induce redistribution of integral membrane proteins. Cell-surface receptor redistribution does not consistently follow electric field lines and depends critically on the frequency of the applied ac electric fields, suggesting that mechanisms other than electroosmosis are involved. We hypothesized that cytoskeletal reorganization is responsible for electric field-induced cell-surface receptor redistribution, and used fluorescence video microscopy to study the reorganization of microfilaments in human hepatoma (Hep3B) cells exposed to low-frequency electric fields ranging in strength from 25 mV/cm to 20 V/cm (peak to peak). The frequency of the applied electric field was varied from 1 to 120 Hz and the field exposure duration from 1 to 60 min. In control cells, cytoplasmic microfilaments were aligned in the form of continuous parallel cables along the longitudinal axis of the cell. Exposure of cells to ac electric fields induced alterations in microfilament structure in a manner that depended on the frequency of the applied field. A 1 or 10 Hz ac field caused microfilament reorganization from continuous, aligned cable structures to discontinuous globular patches. In contrast, the structure of microfilaments in ...Continue Reading

Citations

Oct 27, 2006·Annals of Biomedical Engineering·Ayman HamedMichael Cho
Jan 5, 2007·Medical & Biological Engineering & Computing·I DigelA Temiz Artmann
May 17, 2011·Annals of Medicine·Emilia KaivosojaYrjö T Konttinen
Apr 21, 2018·Scientific Reports·Attilio MarinoGianni Ciofani
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M R ChoD E Golan
Mar 26, 2004·Bioelectromagnetics·Shinji HarakawaDavid E Martin
Jan 18, 2003·Archives of Physiology and Biochemistry·T HeidaE Marani
Sep 21, 2012·Journal of the Royal Society, Interface·Abdul Q SheikhDaria A Narmoneva
Nov 16, 2016·International Journal of Environmental Research and Public Health·Jack A TuszynskiJordane Preto
Aug 31, 2006·Biotechnology Journal·Ruei-Zeng LinHwan-You Chang
Apr 3, 2008·Bioelectromagnetics·Francis X Hart
Jan 5, 2000·Cell Motility and the Cytoskeleton·W KorohodaZ Madeja
May 6, 2004·Cancer Research·Eilon D KirsonYoram Palti
Jun 25, 2021·Advanced Science·Donghui WangXuanyong Liu
Dec 9, 2019·ACS Biomaterials Science & Engineering·Rongrong GuoMingliang Tang
Jan 27, 2009·Progress in Histochemistry and Cytochemistry·Richard H W FunkNurdan Ozkucur

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