Reorganization of Respiratory Descending Pathways following Cervical Spinal Partial Section Investigated by Transcranial Magnetic Stimulation in the Rat

PloS One
Stéphane VinitMichel Petitjean

Abstract

High cervical spinal cord injuries lead to permanent respiratory deficits. One preclinical model of respiratory insufficiency in adult rats is the C2 partial injury which causes unilateral diaphragm paralysis. This model allows the investigation of a particular population of respiratory bulbospinal axons which cross the midline at C3-C6 spinal segment, namely the crossed phrenic pathway. Transcranial magnetic stimulation (TMS) is a non-invasive technique that can be used to study supraspinal descending respiratory pathways in the rat. Interestingly, a lateral C2 injury does not affect the amplitude and latency of the largest motor-evoked potential recorded from the diaphragm (MEPdia) ipsilateral to the injury in response to a single TMS pulse, compared to a sham animal. Although the rhythmic respiratory activity on the contralateral diaphragm is preserved at 7 days post-injury, no diaphragm activity can be recorded on the injured side. However, a profound reorganization of the MEPdia evoked by TMS can be observed. The MEPdia is reduced on the non-injured rather than the injured side. This suggests an increase in ipsilateral phrenic motoneurons excitability. Moreover, correlations between MEPdia amplitude and spontaneous contral...Continue Reading

References

Nov 1, 1991·The Journal of Physiology·D MaskillA Guz
Jan 1, 1986·Experimental Brain Research·J LipskiR Porter
Mar 1, 1987·The Journal of Physiology·S C Gandevia, J C Rothwell
Nov 1, 1996·Respiration Physiology·N J DaveyP H Ellaway
Aug 14, 2001·Experimental Brain Research·A R LuftD F Hanley
Mar 18, 2003·Journal of Applied Physiology·Tarek SharsharMichael I Polkey
Sep 26, 2003·American Journal of Physical Medicine & Rehabilitation·Christopher Winslow, Julia Rozovsky
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francis J Golder, Gordon S Mitchell
Nov 5, 2005·Journal of Applied Physiology·David D FullerGordon S Mitchell
Apr 25, 2006·Experimental Neurology·Kenneth H MinorNicholas W Seeds
Jul 27, 2006·Journal of Neurotrauma·Stéphane VinitAnne Kastner
Feb 13, 2007·NeuroImage·Savio W WongJ Kevin Shoemaker
Jan 20, 2009·Respiratory Physiology & Neurobiology·D D FullerP J Reier
Jun 23, 2009·Respiratory Physiology & Neurobiology·Harry G Goshgarian
Aug 5, 2009·Respiratory Physiology & Neurobiology·Stéphane VinitGordon S Mitchell
Aug 18, 2009·Respiratory Physiology & Neurobiology·Stéphane Vinit, Anne Kastner
Aug 25, 2009·Respiratory Physiology & Neurobiology·Michael A LanePaul J Reier
Feb 22, 2011·Respiratory Physiology & Neurobiology·Stéphane VinitGordon S Mitchell
Jul 15, 2011·Nature·Warren J AlilainJerry Silver
Jul 26, 2011·Respiratory Physiology & Neurobiology·Michael A Lane
Nov 2, 2011·Respiratory Physiology & Neurobiology·James A Windelborn, Gordon S Mitchell
Mar 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary R Lovett-BarrGordon S Mitchell
Oct 4, 2013·Neural Plasticity·Francesco Ferrini, Yves De Koninck
Oct 8, 2013·Frontiers in Behavioral Neuroscience·Kiseko ShionoyaAnne-Marie Mouly
Jun 5, 2014·Journal of Visualized Experiments : JoVE·Emilie KeomaniStéphane Vinit
Jun 28, 2014·The Journal of Spinal Cord Medicine·M Beth ZimmerHarry G Goshgarian
Jan 20, 2015·Neural Regeneration Research·Marcel Bonay, Stéphane Vinit

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Citations

Sep 16, 2016·Neural Regeneration Research·Stéphane Vinit, Michel Petitjean
Apr 28, 2017·Journal of Neurotrauma·Kun-Ze Lee, Shih-Hui Hsu
Aug 29, 2017·Journal of Neurotrauma·Ming-Han Wen, Kun-Ze Lee
Sep 2, 2016·Experimental Neurology·Kristiina M HormigoMichael A Lane

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