Reorganization of retinotopic maps after occipital lobe infarction

Journal of Cognitive Neuroscience
Lucia M VainaA Cowey

Abstract

We studied patient JS, who had a right occipital infarct that encroached on visual areas V1, V2v, and VP. When tested psychophysically, he was very impaired at detecting the direction of motion in random dot displays where a variable proportion of dots moving in one direction (signal) were embedded in masking motion noise (noise dots). The impairment on this motion coherence task was especially marked when the display was presented to the upper left (affected) visual quadrant, contralateral to his lesion. However, with extensive training, by 11 months his threshold fell to the level of healthy participants. Training on the motion coherence task generalized to another motion task, the motion discontinuity task, on which he had to detect the presence of an edge that was defined by the difference in the direction of the coherently moving dots (signal) within the display. He was much better at this task at 8 than 3 months, and this improvement was associated with an increase in the activation of the human MT complex (hMT(+)) and in the kinetic occipital region as shown by repeated fMRI scans. We also used fMRI to perform retinotopic mapping at 3, 8, and 11 months after the infarct. We quantified the retinotopy and areal shifts by m...Continue Reading

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Citations

Feb 13, 2019·Neurorehabilitation and Neural Repair·Ania BuszaBogachan Sahin
Dec 15, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael D MelnickKrystel R Huxlin
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Nov 25, 2020·Current Opinion in Neurology·Elizabeth L SaionzKrystel R Huxlin
Jun 13, 2017·NeuroImage·Dimitris A PinotsisEarl K Miller
Jul 17, 2021·Stroke; a Journal of Cerebral Circulation·Berkeley K FahrentholdKrystel R Huxlin

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