PMID: 9445032Jan 28, 1998Paper

Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins

Journal of Virology
Barbara SherryM A Blum

Abstract

Reovirus-induced acute myocarditis in mice serves as a model to investigate non-immune-mediated mechanisms of viral myocarditis. We have used primary cardiac myocyte cultures infected with a large panel of myocarditic and nonmyocarditic reassortant reoviruses to identify determinants of viral myocarditic potential. Here, we report that while both myocarditic and nonmyocarditic reoviruses kill cardiac myocytes, viral myocarditic potential correlates with viral spread through cardiac myocyte cultures and with cumulative cell death. To address the role of secreted interferon (IFN), we added anti-IFN-alpha/beta antibody to infected cardiac myocyte cultures. Antibody benefited nonmyocarditic more than myocarditic virus spread (P < 0.001), and this benefit was associated with the reovirus M1 and L2 genes. There was no benefit for a differentiated skeletal muscle cell line culture (C2C12 cells), suggesting cell type specificity. IFN-beta induction in reovirus-infected cardiac myocyte cultures correlated with viral myocarditic potential (P = 0.006) and was associated with the reovirus M1, S2, and L2 genes. Sensitivity to the antiviral effects of IFN-alpha/beta added to cardiac myocyte cultures also correlated with viral myocarditic pot...Continue Reading

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Citations

Aug 16, 2005·The Journal of Clinical Investigation·Sean M O'DonnellTerence S Dermody
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Barbara Sherry
May 8, 2013·The Journal of Biological Chemistry·Amanda A AnafuGeoffrey H Holm
Sep 27, 2013·Journal of Virology·Andrea J PruijssersTerence S Dermody
Dec 13, 2002·Rapid Communications in Mass Spectrometry : RCM·Magdalena I SwansonKevin M Coombs
May 29, 2003·The Journal of General Virology·Claudia González-LópezJavier Benavente
Mar 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B A SchoneboomF B Grieder
May 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·P ClarkeK L Tyler
Jun 25, 2020·Viruses·Andrew T Abad, Pranav Danthi
Jan 27, 2005·Viral Immunology·Friedemann WeberOtto Haller
Jan 28, 2006·Journal of Virology·Jennifer A SmithLeslie A Schiff
Jan 30, 2009·Journal of Virology·Takeshi KobayashiTerence S Dermody
Aug 14, 2003·Journal of Virology·J Craig Forrest, Terence S Dermody
Jul 10, 2010·PLoS Pathogens·Pranav DanthiTerence S Dermody
Oct 17, 2012·Heart Failure Reviews·Sabine Pankuweit, Karin Klingel
Oct 17, 2014·Journal of Virology·Mary K McCarthyJason B Weinberg
Jan 13, 2017·Journal of Virology·Efraín E Rivera-SerranoBarbara Sherry
Feb 20, 2019·Veterinary Research·Niccoló VendraminNiels Jørgen Olesen
Dec 19, 2000·Journal of Virology·R L DeBiasiK L Tyler
May 28, 2004·Journal of Virology·Laura L Hermann, Kevin M Coombs
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Jun 3, 2009·Zoonoses and Public Health·R E KahnJ A Richt
May 14, 2010·Journal of Virology·Geoffrey H HolmTerence S Dermody
Sep 13, 2019·Journal of Virology·Roxana M Rodríguez StewartBernardo A Mainou
Aug 28, 2020·Journal of Virology·Katherine E RoebkePranav Danthi
Sep 9, 2017·Scientific Reports·Megan L StaniferSteeve Boulant
Jun 8, 2017·Viruses·Emily J SimonKarl W Boehme

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