Reoxidation of cytosolic NADPH in Kluyveromyces lactis

FEMS Yeast Research
Nuria TarríoM Isabel González Siso

Abstract

Saccharomyces cerevisiae and Kluyveromyces lactis are considered to be the prototypes of two distinct metabolic models of facultatively-aerobic yeasts: Crabtree-positive/fermentative and Crabtree-negative/respiratory, respectively. Our group had previously proposed that one of the molecular keys supporting this difference lies in the mechanisms involved in the reoxidation of the NADPH produced as a consequence of the activity of the pentose phosphate pathway. It has been demonstrated that a significant part of this reoxidation is carried out in K. lactis by mitochondrial external alternative dehydrogenases which use NADPH, the enzymes of S. cerevisiae being NADH-specific. Moreover, the NADPH-dependent pathways of response to oxidative stress appear as a feasible alternative that might co-exist with direct mitochondrial reoxidation.

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Citations

Feb 8, 2013·Applied Microbiology and Biotechnology·Tobias KleinKonstantin Schneider
Sep 1, 2009·Microbial Cell Factories·M Isabel González-SisoM Esperanza Cerdán
Dec 8, 2009·Bioscience, Biotechnology, and Biochemistry·Noppon LertwattanasakulMamoru Yamada
Feb 24, 2012·Microbial Cell Factories·Balaji BalagurunathanRajagopalan Srinivasan
Oct 3, 2012·BMC Genomics·Oscar DiasIsabel Rocha
Jan 12, 2010·Antioxidants & Redox Signaling·Lars M BlankBruno Bühler
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·M Isabel González Siso, M Esperanza Cerdán
Apr 30, 2014·Biotechnology Journal·Oscar DiasIsabel Rocha
Feb 12, 2010·Yeast·A García-LeiroM I González-Siso
Aug 16, 2014·Biochimica Et Biophysica Acta·Dmytro V GospodaryovHoward T Jacobs
Jul 15, 2015·Fungal Genetics and Biology : FG & B·Mónica Lamas-MaceirasMa Esperanza Cerdán
Dec 10, 2014·Applied Microbiology and Biotechnology·Christian LöserThomas Bley
May 28, 2008·FEMS Yeast Research·Michele SaliolaClaudio Falcone
Jun 9, 2009·FEMS Yeast Research·Annamaria MericoConcetta Compagno
Jan 18, 2011·FEMS Yeast Research·Rim Al SafadiMichel Aigle
Jan 29, 2011·Journal of Bioenergetics and Biomembranes·Vicente de Paulo MartinsSérgio Akira Uyemura
Aug 11, 2020·Applied Microbiology and Biotechnology·Biao ZhangFeng Li

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