PMID: 8598363Mar 1, 1996Paper

Reoxygenation after single irradiation in rodent tumors of different types and sizes

International Journal of Radiation Oncology, Biology, Physics
Rumi MurataM Abe

Abstract

To investigate the variation of reoxygenation patterns after single irradiation in murine tumors of different types and sizes. Whole-body single irradiation of 13 to 15 Gy was delivered to 10 mm RIF1 tumors of C3H/He mice, 22 mm SCCVII tumors of C3H/He mice, and 16 mm EMT6 tumors of Balb/c mice. Thereafter, changes in the hypoxic fraction with time were determined by the paired survival curve method. The data were compared with the results we had ++previously obtained with 10 mm SCCVII and 10 mm EMT6 tumors. The hypoxic fraction at 1 h after the priming irradiation was 26% for 10 mm RIF1 tumors, 48% for 10 mm SCCVII tumors, and 100% for 10 mm EMT6 tumors. Thus, RIF1 and SCCVII tumors, both of which have few necrotic areas, showed rapid reoxygenation, whereas EMT6 tumors, which have large necrotic areas, reoxygenated slowly. Although the hypoxic fraction returned to the pretreatment level within 72 h in 10 mm SCCVII and 10 mm EMT6 tumors, it did not in 10 mm RIF1 tumors. In contrast, the patterns of reoxygenation were similar between 22 mm and 10 mm SCCVII tumors and between 16 mm and 10 mm EMT6 tumors. The three tumors showed different patterns of reoxygenation. Tumors that have a low proportion of necrosis may reoxygenate rapi...Continue Reading

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Citations

Jan 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Chikao SugieTakuya Hashizume
Mar 15, 1997·International Journal of Radiation Oncology, Biology, Physics·R MurataM Hiraoka
Dec 18, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·T MuraiY Shibamoto
Jan 8, 2014·Radiation Oncology·Kotoha TatekawaYuta Shibamoto
Feb 4, 2014·BioMed Research International·Antonio SantacroceDaniel Hänggi
May 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuta ShibamotoRyuji Asai
Nov 26, 2011·International Journal of Radiation Oncology, Biology, Physics·Shinya OtsukaHiroyuki Ogino
Sep 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Natsuo TomitaHiromitsu Iwata
Jun 14, 2013·Cell Biochemistry and Function·Andrea B ZepedaJorge G Farías
Mar 24, 2016·Journal of Radiation Research·Yuta ShibamotoHiromitsu Iwata
Apr 2, 2014·International Journal of Radiation Oncology, Biology, Physics·Tyler J BradshawRobert Jeraj
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