PMID: 2497343May 1, 1989Paper

Repair analysis of mitomycin C-induced DNA crosslinking in ribosomal RNA genes in lymphoblastoid cells from Fanconi's anemia patients

Mutation Research
A MatsumotoP C Hanawalt

Abstract

The repair of mitomycin C (MMC)-induced DNA crosslinking was analyzed by denaturation-renaturation gel electrophoresis in ribosomal RNA genes in lymphoblastoid cell lines from 4 patients with Fanconi's anemia (FA). In comparison to normal lymphoblastoid cell lines, 2 lines of FA cells belonging to complementation group A clearly exhibited higher sensitivity to MMC and an almost identical deficiency in the removal of DNA crosslinking. A complementation group B cell line, HSC 62, exhibited a lower sensitivity than group A cells and a lesser deficiency in crosslink repair. Another 'non-A' group cell line, HSC 230, reproducibly exhibited even higher sensitivity to MMC than group A cells. The results on MMC crosslinkage removal at the molecular level correlated well with cell survival. The observed subtle differences of repair among the 4 FA cell lines might represent possible genetic differences in the respective FA complementation groups.

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Citations

Mar 1, 1994·Stem Cells·C C dos SantosM Buchwald
Dec 1, 1992·Mutation Research·D Hellgren
Jul 1, 1991·Mutation Research·K SakaguchiJ B Boyd
Sep 18, 1998·Mutation Research·M Buchwald, E Moustacchi
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Antonio ConconiMichael J Smerdon
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D PapadopouloE Moustacchi
Jul 28, 2004·The American Journal of Pathology·Michiel S van der HeijdenScott E Kern
Oct 5, 1993·Biochemistry·F C Christians, P C Hanawalt
Mar 1, 1989·Jinrui idengaku zasshi. The Japanese journal of human genetics·M S Sasaki
Dec 31, 2009·Critical Reviews in Biochemistry and Molecular Biology·Parameswary A MuniandyMichael M Seidman
Apr 11, 2015·Environmental Microbiology·Brian W KwanThomas K Wood
Dec 26, 2001·Molecular Genetics and Metabolism·Y M AkkariM Grompe

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