PMID: 7035831Jan 1, 1981Paper

Repair and plasmid R46 mediated mutation requires inducible functions in Proteus mirabilis

Molecular & General Genetics : MGG
J Hofemeister, G Eitner

Abstract

In Proteus mirabilis nalidixic acid or a predose of UV induce Rec protein formation, a portion of post-UV replication repair and "post-UV replication enhancement." These inducible functions are not significantly affected by the plasmid R46, which renders P. mirabilis efficiently UV-mutable. The R46-mediated UV induction of rif mutations requires additional inducible functions, as existing after nalidixic acid treatment in rec+ strains. After a nalidixic acid pretreatment UV efficient induction of rif mutations occurs without an otherwise obligatory period of post-UV incubation prior to plating on rifampicin agar. THe inducible character of this "qualification" of plasmid R46-mediated UV mutagenesis in P. mirabilis is evident from the inhibitory effects of chloramphenicol and starvation. Constitutive high-level synthesis of Rec protein in cells harboring the recombinant (multi-copy) rec+ plasmid pPM1 reduced plasmid R46-mediated UV mutagenesis, probably by preventing (inducible?) functions required by the plasmid R46 repair-mutator.

References

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Citations

Jan 1, 1982·Molecular & General Genetics : MGG·G EitnerJ Hofemeister
May 1, 1985·Mutation Research·S G Sedgwick, P A Goodwin
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S G Sedgwick, P A Goodwin
Jan 1, 1987·Environmental and Molecular Mutagenesis·R K Elespuru

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