PMID: 8940753Sep 1, 1996Paper

Repair capacity of mouse lung after total body irradiation alone or combined with cyclophosphamide

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
A SafwatJ Overgaard

Abstract

Cyclophosphamide (CTX) combined with fractionated total body irradiation (TBI) is frequently used in the conditioning of patients prior to bone marrow transplantation (BMT). This study was performed to investigate the effect of CTX on the repair capacity of lung tissue after TBI in a mouse model for BMT. TBI was given as a single fraction, 3 fractions in 3 days (Fx 3) or 9 fractions in 3 days (Fx 9) either alone or 24 h after a single dose of CTX. The single fraction TBI was given at either high dose rate (HDR) of 0.71 Gy/min or low dose rate (LDR) of 0.08 Gy/min. All mice were transplanted 4-6 h after the last TBI fraction. Lung damage was assessed using ventilation rate (VR) and lethality between 28 and 180 days. The repair capacity of lung tissue was estimated using the direct analysis method with the probability of reaching the end point described by a logistic formulation of the linear quadratic model. The VR data confirmed the high repair capacity of lung tissue with an alpha/beta ratio of 4.4 Gy though with a wide 95% confidence interval (CI = 0.03-10.5). Giving CTX before fractionated TBI markedly reduced the doses needed to cause response in 50% of the animals. The sparing effect of using fractionated TBI was still evi...Continue Reading

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Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M Bentzen, S Dische
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·C AristeiP Latini
Mar 9, 2020·Radiation and Environmental Biophysics·K E ApplegateS Bouffler

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