PMID: 9637239Jun 24, 1998Paper

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA

Mutation Research
S DinglayBarbara Sedgwick

Abstract

Escherichia coli alkB mutants are sensitive to methyl methanesulfonate and dimethylsulphate, and are defective in the processing of methylated DNA. The function of the AlkB protein has not been determined. Here, we show that alkB mutants are not defective in repairing several different types of potentially toxic DNA lesions that are known to be generated by MMS, including apyrimidinic and apurinic sites, and secondary lesions that could arise at these sites (DNA-protein cross-links and DNA interstrand cross-links). Also, alkB mutants were not sensitive to MeOSO2-(CH2)2-Lex, a compound that alkylates the minor groove of DNA generating primarily 3-methyladenine.

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Citations

Oct 7, 2003·Research in Microbiology·Pål Ø Falnes, Torbjørn Rognes
Oct 24, 2009·Accounts of Chemical Research·Chengqi YiChuan He
Feb 9, 2006·Chemical Reviews·Yukiko MishinaChuan He
Nov 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zoulikha M ZaïrGeorge E Johnson
Mar 4, 2014·Chemical Reviews·Guanqun ZhengChuan He
Jan 27, 2004·Journal of Cellular Biochemistry·Gilberto Fronza, Barry Gold
Mar 26, 2004·Nature Reviews. Molecular Cell Biology·Barbara Sedgwick
Aug 24, 2019·The Journal of Biological Chemistry·Liewei L Yan, Hani S Zaher
Sep 22, 2005·The Journal of Biological Chemistry·Dong-Hyun LeeTimothy R O'Connor
Sep 12, 2020·The Journal of Biological Chemistry·Yu XuHashim M Al-Hashimi
Feb 14, 2006·Journal of Inorganic Biochemistry·Yukiko Mishina, Chuan He

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