PMID: 8601751Jan 1, 1996Paper

Repair kinetics in pig epidermis: an analysis based on two separate rates of repair

International Journal of Radiation Biology
W T MillarP A Canney

Abstract

Pig skin was irradiated using 90Sr/90Y plaques and the dose-related incidence of induced moist desquamation was determined. The repair of radiation-induced sublethal damage (SLD) was studied by fitting these response data to the generalized LQ equation for incomplete repair using quasilikelihood methods with binomial statistics, and either a Poisson or logistic link to relate the probability of response to the covariates. A Poisson response analysis based on the assumption that SLD was governed by two repair processes gave estimated repair half-times of 0.20 [(95% confidence limits) 0.12, 0.34] and 6.6 [4.3, 10.0] h. The estimates of the short and long repair half-times were significantly different, although there was no significant difference between the results using the Poisson and logistic modes of analyses. The partition coefficient for the longer repair process was 0.5 [0.34, 0.71] indicating that about 33% of SLD-derived lethal damage is associated with the longer repair process in the case of 'complete repair' protocols. However, this proportionation is, in general, protocol dependent for incomplete repair protocols. A chi2 test on the residual deviance showed that the assumption of two repair processes for SLD gave a s...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K K AngY Feng
Apr 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Rojas, M C Joiner
Jun 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I Turesson, H D Thames
Jun 1, 1986·The British Journal of Radiology·J H Hendry, H D Thames
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen
Aug 1, 1994·International Journal of Radiation Biology·W T MillarP A Canney

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Citations

Jan 22, 2017·Radiation Oncology·Carsten HerskindFrederik Wenz
Aug 1, 1997·The British Journal of Radiology·P A Canney, W T Millar
Jun 6, 2019·Radiation Research·Luke R BurnettMichael Tytell
Oct 4, 2002·Physics in Medicine and Biology·M GuerreroX Allen Li
Aug 6, 1998·The British Journal of Radiology·R G Dale, B Jones
Nov 24, 2004·Physics in Medicine and Biology·David J CarlsonM Guerrero

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