Repair of articular cartilage defects with cultured chondrocytes on polysulphonic membrane: experimental studies in rabbits

Transplantation Proceedings
M PłończakJ Kawiak

Abstract

Autologous osteochondral transplantation is one method that can be used to create hyaline or hyaline-like repair in a defect area. The purpose of the present study was to repair full-thickness articular cartilage defects in 9 rabbit knee joints with autologous cultured chondrocytes. An articular cartilage defect was created on the patellar groove of the femur. The defect was filled with chondrocytes cultured in vitro and placed into the knee on a polysulphonic membrane. At 8 weeks after the operation, the reparative tissue was analyzed macroscopically and histologically. At 8 weeks after the operation, the surfaces of the reparative tissue were smooth, and the defects were filled with mature hyaline cartilage in 5 cases. In 2 cases, the reparative hyaline cartilage was immature and there was worse integration of grafted tissue into the adjacent normal cartilage. In 2 cases, the surface of the grafted area was irregular, and the reparative tissue was disintegrated and incompletely differentiated. The results suggest that transplantation of autologous chondrocytes cultured in vitro and placed into the knee on polysulphonic membrane is effective in repairing an articular cartilage defect.

References

Oct 1, 1990·Current Opinion in Rheumatology·S B Trippel
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson

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Citations

May 18, 2013·Indian Journal of Orthopaedics·Amit RastogiRavindra Pratap Singh
Jul 8, 2011·Injury·Javier Vaquero, Francisco Forriol
Dec 23, 2008·Osteoarthritis and Cartilage·B J AhernT P Schaer
Mar 7, 2019·Plant Disease·Katherine E EastMichelle M Moyer

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