Repair of canine mandibular bone defects with bone marrow stromal cells and coral

Tissue Engineering. Part a
Jie YuanYilin Cao

Abstract

Tissue engineering has become a new approach for repairing bone defects. Previous studies indicated that coral scaffolds had been utilized with bone marrow stromal cells (BMSCs) in a variety of approaches for bony reconstruction. In these applications, the degradation rate of the material did not match the rate at which bone was regenerated. In this study, a previously established 30 mm long mandibular segmental defect was repaired with engineered bone using green fluorescent protein-labeled osteogenic BMSCs seeded on porous coral (n = 12). Defects treated with coral alone (n = 12) were used as an experimental control. In the BMSCs/coral group, new bone formation was observed from 4 weeks postoperation, and bony-union was achieved after 32 postoperative weeks. The residual coral volume of the BMSCs/coral grafts at 12 weeks (20-30%) was significantly higher than that at 32 weeks (10-15%, p < 0.05), which was detected by microcomputed tomography and histological examination. The engineered bone with BMSCs/coral achieved satisfactory biomechanical properties at 32 weeks postoperation, which was very close to that of the contralateral edentulous mandible. More importantly, immunostaining demonstrated that the implanted BMSCs differ...Continue Reading

References

May 1, 1987·Journal of Biomedical Materials Research·G GuilleminM Chetail
Nov 1, 1988·Cell and Tissue Research·C ManiatopoulosA H Melcher
Aug 1, 1995·Journal of Biomedical Materials Research·M RoudierR Jeandot
Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E HarrisG R Mundy
Mar 14, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M F SciadiniK D Johnson
Jun 11, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S P BruderS Kadiyala
Aug 11, 1998·The Journal of Bone and Joint Surgery. American Volume·S P BruderS Kadiyala
Jun 23, 2000·The Journal of Clinical Investigation·P Bianco, P Gehron Robey
Sep 6, 2000·Nature Biotechnology·H PetiteG Guillemin
Feb 7, 2002·International Journal of Oral and Maxillofacial Surgery·H SchliephakeM Tauscher
Apr 2, 2002·Biomaterials·Jörg HandschelUlrich Joos
Oct 18, 2003·The Journal of Bone and Joint Surgery. American Volume·Treena Livingston ArinzehSudha Kadiyala
May 4, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Haru AbukawaMaria J Troulis
Feb 24, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Véronique ViateauHervé Petite

❮ Previous
Next ❯

Citations

Jun 18, 2011·Frontiers of Medicine·Hengyun SunYilin Cao
Sep 10, 2011·Tissue Engineering. Part B, Reviews·Scott J Hollister, William L Murphy
Jul 20, 2013·Tissue Engineering. Part B, Reviews·Nattharee ChanchareonsookJohn A Jansen
Nov 30, 2010·Stem Cells International·Anindita ChatterjeaJan de Boer
May 1, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Susan W Volk, Christine Theoret
Nov 22, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nattharee ChanchareonsookJohn Jansen
Oct 18, 2013·Clinical Implant Dentistry and Related Research·Shaoyi WangZhiyuan Zhang
Apr 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Edwin L CooperPaul W Sammarco
May 12, 2012·Clinical Spine Surgery : a Spine Publication·Wencheng YangXujun Chen
Sep 16, 2018·Materials·Ana S Neto, José M F Ferreira
Dec 5, 2017·Experimental and Therapeutic Medicine·Xiuli Shan, Deshan Hu
May 1, 2021·Journal of Dental Research, Dental Clinics, Dental Prospects·Ali Hossein MesgarzadehHajar Shafaei
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian YinXinhui Liu
Jan 14, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Vinicius RosaJacques Eduardo Nör

❮ Previous
Next ❯

Methods Mentioned

BETA
Scanning electron microscopy
X-ray

Software Mentioned

Image Pro Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.