PMID: 8969759Dec 1, 1996Paper

Repair of chronic tympanic membrane perforations with fibroblast growth factor

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
M Kato, Robert K Jackler

Abstract

A number of angiogenic growth factors have been shown to accelerate wound healing. Previous work has demonstrated that topical application of epidermal growth factor is effective in healing chronic tympanic membrane perforations in an animal model. Theoretically, fibroblast growth factor may result in a superior healed membrane through preferential stimulation of the fibroblasts within the middle layer of the tympanic membrane. To test this hypothesis, the effects of exogenously applied fibroblast growth factor on the chronically perforated tympanic membrane were evaluated. A buffered solution of fibroblast growth factor (25 microliters of fibroblast growth factor, 0.2 mg/ml) was administered to a Gelfoam pledget placed over chronic tympanic membrane perforations in chinchillas. Control ears were treated with Gelfoam and the buffer solution only. Complete closure of the tympanic membrane perforation was observed in 81% (13 of 16) of the fibroblast growth factor-treated ears, but in only 41% (7 of 17) of the controls (p = 0.05). Heading took place gradually, requiring an average of 4 weeks for the fibroblast growth factor-treated and 6.5 weeks for the control ears that healed. The relatively high healing rate for the control gro...Continue Reading

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Citations

Oct 4, 2012·Tissue Engineering. Part B, Reviews·Bing Mei TehMarcus D Atlas
Nov 27, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaTadahiko Wada
Sep 8, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Shin-Ichi KanemaruJuichi Ito
Mar 10, 2016·American Journal of Otolaryngology·Zhengcai LouJiang Chang
Apr 10, 2009·The Laryngoscope·Aron ParekhPatricia A Hebda
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jin KimKwang Gill Lee
Jun 16, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Peter Luke Santa MariaYunzhi Peter Yang
Dec 4, 2014·Mayo Clinic Proceedings·David G Lott, Jeffrey R Janus
May 20, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery· Jian-Yang
Aug 12, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zheng-Cai Lou
Mar 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R C O'ReillyS P Cass
Mar 14, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·D Bradley Welling, Robert K Jackler
Jul 19, 2018·The Journal of Laryngology and Otology·Z-C LouJ Xiao
Feb 13, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaKiyofumi Gyo
Nov 10, 2007·Current Opinion in Neurology·Ashkan MonfaredRobert K Jackler
Aug 31, 2020·Laryngoscope Investigative Otolaryngology·Felipe SantosD Bradley Welling
Jan 22, 2021·Vestnik otorinolaringologii·V M SvistushkinM V Svistushkin
Nov 12, 2015·Audiology Research·Maria A Villar-Fernandez, Jose A Lopez-Escamez
Jul 27, 2021·Stem Cells International·Zhengcai LouZhengnong Chen

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