Repair of Complete Atrioventricular Septal Defects With Decellularized Extracellular Matrix: Initial and Midterm Outcomes

World Journal for Pediatric & Congenital Heart Surgery
Adeel AshfaqBrian Reemtsen

Abstract

Since April 2010, our institution has repaired complete atrioventricular septal defects (CAVSDs) with a two-patch technique utilizing CorMatrix extracellular material. This material is potentially an attractive patch because of its theorized eventual integration with the host tissue. We sought to analyze initial outcomes of CAVSD repair with CorMatrix. Data were collected on consecutive pediatric (age <18) patients receiving two-patch CAVSD repairs with CorMatrix at a single institution from April 2010 to July 2014. Baseline and perioperative characteristics were evaluated. Echocardiograms were evaluated in both the immediate postoperative period and the most recent postoperative follow-up. Variables analyzed included left AV valve performance, residual shunting, left ventricular outflow tract (LVOT) gradient, morbidity, and mortality. Fifteen patients were identified. The average age at operation was 205 days, with mean follow-up time at 1,364 days. Echocardiograms revealed the following: 12 (80%) patients showed either improved or stable left AV valve performance remaining at "mild" or less insufficiency, while two (13%) declined from "none" to mild and one (7%) from mild to "severe," which required reoperation. There was no ...Continue Reading

References

Apr 17, 2007·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Graham R Nunn
Nov 7, 2007·Seminars in Thoracic and Cardiovascular Surgery·Carl Lewis BackerConstantine Mavroudis
Nov 27, 2007·The Annals of Thoracic Surgery·Carl L BackerConstantine Mavroudis
Sep 30, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Samantha E ParkerUNKNOWN National Birth Defects Prevention Network
Aug 30, 2011·The Annals of Thoracic Surgery·Aditya K KazaUNKNOWN Pediatric Heart Network Investigators
Aug 3, 2013·Rambam Maimonides Medical Journal·David Kalfa, Emile Bacha
Sep 6, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Hayrullah AlpAli Sarıgül
Dec 18, 2013·The Journal of Thoracic and Cardiovascular Surgery·Marc W GerdischMichael D Barron
Jun 7, 2015·The Journal of Thoracic and Cardiovascular Surgery·Salil GindeMichael G Earing

❮ Previous
Next ❯

Citations

Jun 20, 2019·Asian Cardiovascular & Thoracic Annals·Paul Philipp HeinischAlexander Kadner
Jun 15, 2018·Frontiers in Pediatrics·Antonio F CornoBranko Mimic
Mar 13, 2021·Xenotransplantation·Héctor Capella-Monsonís, Dimitrios I Zeugolis

❮ Previous
Next ❯

Software Mentioned

CorMatrix

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.