PMID: 2121936Jun 1, 1990Paper

Repair of furocoumarin-plus-UVA-induced damage and mutagenic consequences in eukaryotic cells

Journal of Photochemistry and Photobiology. B, Biology
D AverbeckN Magaña-Schwencke

Abstract

In the presence of near-UV radiation (UVA) furocoumarins (psoralens) photoinduce defined lesions in DNA, i.e. monoadducts and interstrand crosslinks. Their use in photochemotherapy (psoralen plus UVA (PUVA) treatment) and cosmetics raises questions concerning the repairability of these lesions and their genotoxic consequences. We have analysed the repair of psoralen photoadducts in cultured eukaryotic cells, such as yeast and mammalian cells, for furocoumarins of photochemotherapeutic interest. In yeast, the interaction of repair pathways differs in exogenous (plasmid) and endogenous (chromosomal) DNA. The order of mutagenic activity is 4,5',8-trimethylpsoralen greater than 5-methoxypsoralen greater than 8-methoxypsoralen greater than 7-methylpyrido[3,4-c]psoralen greater than 3-carbethoxypsoralen. The mutagenicity is dependent on psoralen functionality, concentration and bioavailability, maximal UVA dose, wavelength, dose (fluence) rate and presence or absence of chemical filters. It probably involves an inducible component. Chromosome breakage occurs during the repair period after PUVA treatment. It appears that the genotoxic effects of psoralens are produced by a specific arrangement of induced photolesions and the interacti...Continue Reading

References

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Citations

Jun 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·D AverbeckE Sage
Jan 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·O KleinauB Lanto
Jul 1, 1992·Experimental Dermatology·P Calzavara-PintonG De Panfilis
Dec 1, 1989·Photochemistry and Photobiology·D Averbeck
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Karen M VasquezPeter M Glazer
Dec 25, 2002·The Tohoku Journal of Experimental Medicine·Zuhal HamurcuEkrem Aktas
Sep 9, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bernd Epe
Aug 1, 1992·Molecular & General Genetics : MGG·J J BoesenJ W Simons
Mar 9, 2002·Molecular and Cellular Biology·Nianxiang ZhangRandy J Legerski
Sep 15, 1992·Journal of Photochemistry and Photobiology. B, Biology·J CadetL Voituriez
Jun 17, 2021·Photochemistry and Photobiology·Maurício S BaptistaAndrés H Thomas

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