Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Nucleic Acids Research
Tapas K HazraS Mitra

Abstract

8-oxoguanine (8-oxoG), induced by reactive oxygen species and arguably one of the most important mutagenic DNA lesions, is prone to further oxidation. Its one-electron oxidation products include potentially mutagenic guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) because of their mispairing with A or G. All three oxidized base-specific DNA glycosylases of Escherichia coli, namely endonuclease III (Nth), 8-oxoG-DNA glycosylase (MutM) and endonuclease VIII (Nei), excise Gh and Sp, when paired with C or G in DNA, although Nth is less active than the other two. MutM prefers Sp and Gh paired with C (kcat/K(m) of 0.24-0.26 min(-1) x nM(-1)), while Nei prefers G over C as the complementary base (k(cat)/K(m) - 0.15-0.17 min(-1) x nM(-1)). However, only Nei efficiently excises these paired with A. MutY, a 8-oxoG.A(G)-specific A(G)-DNA glycosylase, is inactive with Gh(Sp).A/G-containing duplex oligonucleotide, in spite of specific affinity. It inhibits excision of lesions by MutM from the Gh.G or Sp.G pair, but not from Gh.C and Sp.C pairs. In contrast, MutY does not significantly inhibit Nei for any Gh(Sp) base pair. These results suggest a protective function for MutY in preventing mutation as a result of A (G) incorporation op...Continue Reading

References

Aug 25, 1992·Nucleic Acids Research·R C de OliveiraC F Menck
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T J McBrideL A Loeb
Jan 8, 1991·Biochemistry·T J McBrideL A Loeb
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J TchouS Nishimura
Dec 15, 1987·Biochemistry·Y W Kow, S S Wallace
Nov 1, 1994·International Journal of Radiation Biology·J F Ward
Feb 8, 1994·Biochemistry·R J MelamedeS S Wallace
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jul 1, 1993·Trends in Genetics : TIG·A P Grollman, M Moriya
Aug 22, 1996·Nature·D B HallJ K Barton
Mar 1, 1997·Toxicology and Applied Pharmacology·A R OllerG Oberdörster
Jan 24, 1998·The Journal of Biological Chemistry·D JiangS S Wallace
Jun 15, 2000·Journal of Bacteriology·M M Samrakandi, F Pasta

❮ Previous
Next ❯

Citations

Nov 26, 2003·Mutation Research·Svein Bjelland, Erling Seeberg
Nov 26, 2003·Mutation Research·Jean CadetJean-Luc Ravanat
Dec 25, 2002·Journal of Molecular Biology·Varatharasa ThiviyanathanDavid G Gorenstein
Aug 21, 2003·Computational Biology and Chemistry·Miroslav Pinak
Jul 12, 2012·Chemical Research in Toxicology·Craig J Yennie, Sarah Delaney
Oct 19, 2007·Chemical Research in Toxicology·Sarah DelaneyJohn M Essigmann
Jun 22, 2007·Nature·Sheila S DavidSucharita Kundu
Feb 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Minmin LiuSusan S Wallace
Apr 14, 2011·Nucleic Acids Research·Yann-Vaï Le BihanBertrand Castaing
Aug 29, 2006·Journal of Bacteriology·Aurélie MathieuJ Pablo Radicella
Jan 26, 2016·Chemical Research in Toxicology·Brian GruessnerElizabeth Jamieson
Mar 12, 2013·Journal of Photochemistry and Photobiology. B, Biology·Afzal ShahHidayat Hussain
Jun 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Carlos D CarneiroGlaucia R Martinez
Apr 5, 2005·Journal of Computational Chemistry·Hirofumi FujimotoHideaki Maekawa
Jul 10, 2003·Chembiochem : a European Journal of Chemical Biology·Christoph MeyerBernd Giese
Jun 23, 2006·Chemistry : a European Journal·Geneviève Pratviel, Bernard Meunier
Nov 23, 2006·DNA Repair·Zhanna K NazarkinaJ Pablo Radicella
Mar 17, 2015·Mutation Research·Ana Helena Sales de OliveiraLucymara Fassarella Agnez-Lima
Apr 14, 2016·Biochemistry·Erika M NorabuenaMegan E Núñez
May 21, 2013·Bioorganic & Medicinal Chemistry·Toshinori SuzukiMichiyo Inukai
Jul 14, 2007·DNA Repair·Viswanath BandaruSusan S Wallace
Oct 25, 2011·Molecular Aspects of Medicine·Zsolt RadakErika Koltai
Aug 13, 2013·Journal of the American Chemical Society·Paige L McKibbinSheila S David
Feb 17, 2007·Neuroscience·E Trushina, C T McMurray
Apr 4, 2006·Radiation Research·Han-Chun DeFedericisHarold C Box
May 18, 2007·The Journal of Biological Chemistry·David J BakerTimothy R O'Connor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.