PMID: 7026973Jan 1, 1981Paper

Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system

Molecular & General Genetics : MGG
W J JachymczykP J Hastings

Abstract

We have studied the role of the excision-repair system and the recombination-repair system in the removal of cross-links and monoadducts caused by furocoumarins plus 360 nm radiation in yeast DNA by neutral and alkaline sucrose gradients and by a fluorometric procedure which detects cross-linked DNA molecules. We found that the excision-repair system, represented by the rad3 mutations, is required both for the removal of monoadducts, causing single-strand break formation, and for the removal of cross-links, causing double-strand break formation. The recombination-repair system, represented by the rad51 mutation, is necessary for double-strand break repair following cross-link removal, but it has no role in the repair of monoadducts. It can be concluded, that at least some of the same enzymes are used in yeast for both the excision of pyrimidine dimers and the excision of cross-links or monoadducts caused by furocoumarins plus light. The RAD3 and RAD51 repair systems, which act independently in the repair of UV-induced lesions, are part of a single system for the repair of cross-links.

References

Jul 1, 1976·Cell·M A Forte, W L Fangman
Jan 1, 1976·Mutation Research·B R ScottG R Mohn
Oct 10, 1979·Nucleic Acids Research·A R MorganD H Evans
Jun 1, 1979·Photochemistry and Photobiology·P S Song, K J Tapley
Apr 1, 1978·Chemico-biological Interactions·F Dall'AcquaM Recher
Jan 16, 1976·Molecular & General Genetics : MGG·M A Resnick, P Martin
Feb 1, 1976·Genetics·C W Lawrence, R Christensen
Jun 1, 1976·Journal of Theoretical Biology·M A Resnick
Oct 2, 1975·Radiation and Environmental Biophysics·D AverbeckR K Biswas
Jul 23, 1975·Biochimica Et Biophysica Acta·D Averbeck, E Moustacchi
Nov 1, 1975·Journal of Immunological Methods·N M HadlerD S Gordon
Mar 15, 1976·Experientia·N J Deacon, A Ebringer
Jul 2, 1973·European Journal of Biochemistry·M Gross-BellardP Chambon
Nov 27, 1974·Biochemical and Biophysical Research Communications·A R Morgan, D E Pulleyblank
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T D Petes, W L Fangman
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R S Cole
Sep 1, 1974·Mutation Research·J C Game, R K Mortimer
Jul 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·E P GEIDUSCHEK
Aug 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·V N IYER, W SZYBALSKI

❮ Previous
Next ❯

Citations

Sep 1, 1993·Current Genetics·W SuszekW J Jachymczyk
Jun 1, 1989·Molecular & General Genetics : MGG·H H de AndradeJ A Henriques
Aug 1, 1983·Chemico-biological Interactions·S N ChatterjeeJ Basak
Dec 1, 1992·Mutation Research·P J Hastings
Jun 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·D AverbeckE Sage
Dec 4, 2003·Mutation Research·Martin BrendelJoão Antonio Pegas Henriques
Aug 23, 2001·Mutation Research·M L Dronkert, R Kanaar
Dec 12, 2001·Mutation Research·K F GrossmannR E Moses
Jan 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·O KleinauB Lanto
Feb 9, 2006·Chemical Reviews·David M NollPaul S Miller
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N Magaña-SchwenckeE Moustacchi
Apr 11, 1993·Nucleic Acids Research·O BezzubovaJ M Buerstedde
Sep 8, 2011·Genes & Development·Anderson T WangPeter J McHugh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.