Repair of large chondral defects of the knee with autologous chondrocyte implantation in patients 45 years or older

The American Journal of Sports Medicine
Ralf RosenbergerTom Minas

Abstract

Autologous chondrocyte implantation (ACI) has become an accepted option for the treatment of chondral defects in carefully selected patients. Current recommendations limit this procedure to younger patients, as insufficient data are available to conclusively evaluate outcomes in patients older than 45 years. Cartilage repair with ACI in patients older than 45 years results in substantially different outcomes than those previously reported for younger age groups. Case series; Level of evidence, 4. This prospective cohort study reviewed patients > or =45 years of age at the time of treatment with ACI. The clinical evaluation included a patient satisfaction questionnaire and four validated rating scales: Short Form-36, Modified Cincinnati Rating Scale, WOMAC (Western Ontario and McMaster Universities) Osteoarthritis Index, and the Knee Society Score. A total of 56 patients > or =45 years of age were treated with ACI. The average patient age at index surgery was 48.6 years (range, 45-60 years). The minimum follow-up was 2 years (range, 2-11 years; mean, 4.7 years). The cohort included 36 men and 20 women. The mean transplant size was 4.7 cm(2) per defect (range, 1-15.0 cm(2)) and 9.8 cm(2) per knee (range, 2.5-31.6 cm(2)). Twenty-e...Continue Reading

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS

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