Repair of long bone defects with demineralized bone matrix and autogenous bone composite.

Indian Journal of Orthopaedics
Mehmet T Ozdemir, Mustafa Ç Kir

Abstract

Repair of diaphyseal bone defects is a challenging problem for orthopedic surgeons. In large bone defects the quantity of harvested autogenous bone may not be sufficient to fill the gap and then the use of synthetic or allogenic grafts along with autogenous bone becomes mandatory to achieve compact filling. Finding the optimal graft mixture for treatment of large diaphyseal defects is an important goal in contemporary orthopedics and this was the main focus of this study. The aim of this study is to investigate the efficacy of demineralized bone matrix (DBM) and autogenous cancellous bone (ACB) graft composite in a rabbit bilateral ulna segmental defect model. Twenty-seven adult female rabbits were divided into five groups. A two-centimeter piece of long bone on the midshaft of the ulna was osteotomized and removed from the rabbits' forearms. In group 1 (n=7) the defects were treated with ACB, in group 2 (n=7) with DBM, and in group 3 (n=7) with ACB and DBM in the ratio of 1:1. Groups 4 and 5, with three rabbits in each group, were the negative and positive controls, respectively. Twelve weeks after implantation the rabbits were sacrificed and union was evaluated with radiograph (Faxitron), dual-energy x-ray absorptiometry (DEX...Continue Reading

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Citations

Jan 26, 2013·Journal of Tissue Engineering and Regenerative Medicine·Hassan BabikerSøren Overgaard
Jun 14, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Matthew A SoicherDavid P Fyhrie
Apr 3, 2012·World Journal of Stem Cells·Fabiany da Costa GonçalvesElizabeth Obino Cirne-Lima
Aug 8, 2020·Der Unfallchirurg·Matthias Miska, Gerhard Schmidmaier
Apr 11, 2019·Regenerative Biomaterials·Danial BaratiEsmaiel Jabbari

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Methods Mentioned

BETA
chips

Software Mentioned

NCSS ( Number Cruncher Statistical System )
PASS

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