Repair of myelin disease: strategies and progress in animal models

Molecular Medicine Today
I D DuncanS C Zhang

Abstract

Myelin disorders form an important group of human neurological diseases that are as yet incurable. Recent studies on experimental remyelination have suggested that it might be feasible to repair the CNS, either by transplanting normal myelinating cells or by enhancing endogenous repair. Progress in animal models, particularly in transplanting cells of the oligodendrocyte lineage, has resulted in significant focal remyelination and physiological evidence of restoration of function. These data suggest that focal lesions in multiple sclerosis could be repaired by the transplantation of myelin-forming cells. Future therapies could involve both transplantation and promotion of endogenous repair, and the two approaches could be combined with ex vivo manipulation of the donor tissue.

References

Aug 1, 1979·Experimental Brain Research·S G JacobsonW I McDonald
Jan 1, 1992·Developmental Neuroscience·I D DuncanP M Wood
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L YaoH D Webster
Jul 1, 1995·Trends in Neurosciences·M Dubois-Dalcq
Dec 1, 1994·Brain : a Journal of Neurology·K OzawaH Lassmann
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T K MorrisseyR P Bunge
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·U TontschI D Duncan
Jan 1, 1994·Annals of Neurology·A Compston
Oct 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L VignaisM Gumpel
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D A UtzschneiderI D Duncan
Jul 1, 1995·Brain Pathology·I D Duncan, E A Milward
Apr 1, 1996·Neuropathology and Applied Neurobiology·I D Duncan
Aug 1, 1996·Trends in Neurosciences·J E Merrill, E N Benveniste
Jan 1, 1997·Journal of Anatomy·I D Duncan, R L Hoffman
Feb 1, 1997·Journal of Anatomy·A CompstonN Scolding
Jun 1, 1997·Current Opinion in Neurology

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Citations

Mar 16, 2011·Archives of Neurology·Steven A Goldman
Mar 9, 2007·Journal of Neurology·Claire Rice, Neil Scolding
Apr 26, 2006·Current Neurology and Neuroscience Reports·Martin Stangel, Corinna Trebst
Jun 14, 2005·Journal of the Neurological Sciences·Chao ZhaoRobin J M Franklin
Jan 18, 2003·Progress in Neurobiology·Martin Stangel, Hans-Peter Hartung
May 22, 2002·Academic Radiology·Jeff W M BulteJoseph A Frank
Oct 26, 1999·Molecular Medicine Today·L S ShihabuddinF H Gage
Jul 10, 2003·Lancet Neurology·Christopher HalfpennyNeil Scolding
May 20, 2008·Expert Reviews in Molecular Medicine·Karen J Woodward
Jan 18, 2002·The New England Journal of Medicine·Ansi ChangBruce D Trapp
Jul 18, 2008·Human Molecular Genetics·Steven A GoldmanMartha S Windrem
Sep 6, 2001·Pharmacogenomics·K Woodward, S Malcolm
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Claire RiceNeil Scolding
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Paul J Reier
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J W BulteJ A Frank
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bruno StankoffBernard Zalc
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·B D YandavaE Y Snyder
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C ZhangI D Duncan
Feb 11, 2004·Experimental Neurology·Laurent MagyAnne Baron-Van Evercooren
Mar 6, 2003·The Anatomical Record. Part B, the New Anatomist·Robin J M Franklin
Jul 19, 2008·Stem Cells·Tamara GlaserOliver Brüstle
Feb 2, 2011·Experimental Neurology·Masanori SasakiJeffery D Kocsis
Apr 23, 2004·Expert Opinion on Investigational Drugs·Martin Stangel
Jul 3, 2009·Cell Stem Cell·Kinarm KoHans R Schöler
Sep 15, 2014·Clinical Therapeutics·Michael D Carrithers
Dec 14, 2002·Genesis : the Journal of Genetics and Development·Nathalie H DoerflingerBrian Popko
Oct 27, 1998·Journal of Neuroscience Research·S C ZhangI D Duncan
May 18, 2000·Nature Neuroscience·A Björklund, O Lindvall
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lillian S DeBruinGeorge Harauz
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Istvan PirkoMoses Rodriguez
Sep 28, 1999·Current Opinion in Neurology·B D TrappR Rudick
Oct 16, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tamara GlaserOliver Brüstle
Jul 21, 1999·Journal of Neuroscience Research·W E GreverI D Duncan

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