Jan 1, 1990

Repair of radiation induced DNA damages in unicellular green algae

Acta Biologica Hungarica
S G ChankovaA B Syemov

Abstract

Two cell repair systems--photoreactivation and repair of single-strand DNA breaks have been studied using unicellular green algae as a test-system. Effects of the genotype and the intensity of pico/second UV-laser irradiation on the degree of the photoreactivation have been investigated. It has been shown that the lower intensity (I = 8.10(6) W/cm2) effects less the inactivation of living cells comparing with I = 30.10(6) W/cm2, regardless of the genotype. The clearly expressed higher potentials of strains LARG-1 and 260 to produce and repair alterations of the cyclobutane-pyrimidine dimers type have been established. An analysis of DNA degradation during gamma rays irradiation and after incubation has been carried out for investigation the relationship between strains radioresistance and repair of single-strand break. It has been shown that high efficiency of the repair system is characteristic of the resistant strain obtained from chronically irradiated population.

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Mentioned in this Paper

Base Excision Repair
Chlorophyta
ARHGEF12 wt Allele
DNA Damage
Pyrimidine Dimers
Genotoxic Stress
X-Rays, Nuclear
Radiation Tolerance
Genotype Determination
ARHGEF12 gene

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