Repairing process in the transected muscle fibers of the mouse tibialis anterior

Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō
Michiko MatsumotoAkinori Miki

Abstract

Repairing process at the injury site in the transected muscle fibers of the mouse tibialis anterior was studied by light and electron microscopy. Immediately after the transection, the cut end (approximately 10 µm) was filled with dense network of disorganized myofilaments, in which disrupted membranous structures and degraded mitochondria were scattered. In the portion next to the portion exhibiting sudden necrotic changes, morphological features of the myofilaments, mitochondria and membranous structures appeared to be almost normal. The degradation of disorganized myofilaments at the cut end began within 1 hour after the transection, and at 1hour after the transection, the degenerating areas were noted in most of muscle fibers up to 150-250 µm from the cut end. Following the degradation, accumulation of mitochondria occurred between the necrotic and myofilament-predominant living portions, and several transverse tubules (T-tubules) and sarcoplasmic reticula were found between the mitochondria-accumulated and myofilament-predominant areas. In most cases, demarcation membrane formed between the mitochondria-accumulated and myofilament-predominant areas, and the fusion of T-tubules and sarcoplasmic reticula was encountered in t...Continue Reading

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