Repairing subtelomeric DSBs at the nuclear periphery

Trends in Cell Biology
Angela Taddei, Susan M Gasser

Abstract

Nuclear organization creates microenvironments favoring distinct nuclear functions. In budding yeast, silent chromatin regions such as telomeres are clustered at the nuclear periphery, creating zones of transcriptional repression. Recently, in the Journal of Cell Biology, Therizols et al. report that "telomere tethering at the nuclear periphery is essential for DNA double strand break repair in subtelomeric regions". Here, we discuss these results and their functional implications.

Citations

Apr 24, 2010·Nature Reviews. Molecular Cell Biology·Karim Mekhail, Danesh Moazed
Feb 15, 2012·Seminars in Cancer Biology·Clara Lopes Novo, J Arturo Londoño-Vallejo
Jan 8, 2011·Cell Cycle·Tasuku KitadaMichael Grunstein
Oct 6, 2016·Mechanisms of Ageing and Development·Kalliopi StratigiGeorge A Garinis

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