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Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences

Proceedings of the National Academy of Sciences of the United States of America

Jul 19, 2001

Z H ZhouMaria Jasin

Abstract

Genetic instability can be induced by unusual DNA structures and sequence repeats. We have previously demonstrated that a large palindrome in the mouse germ line derived from transgene integration is extremely unstable and undergoes stabilizing rearrangements at high frequency, often th...read more

Mentioned in this Paper

Mice, Inbred CBA
Polaron
Recombination, Genetic
Recombinant Transgenes
Palindromic Rheumatism
Homologous Recombination
Strand Invasion
Recombinants
Founder Mice, Transgenic
Transgenes
Paper Details
References
  • References32
  • Citations29
1234
  • References32
  • Citations29
123

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AT-rich palindromes mediate the constitutional t(11;22) translocation

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Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences

Proceedings of the National Academy of Sciences of the United States of America

Jul 19, 2001

Z H ZhouMaria Jasin

PMID: 11459971

DOI: 10.1073/pnas.151008498

Abstract

Genetic instability can be induced by unusual DNA structures and sequence repeats. We have previously demonstrated that a large palindrome in the mouse germ line derived from transgene integration is extremely unstable and undergoes stabilizing rearrangements at high frequency, often th...read more

Mentioned in this Paper

Mice, Inbred CBA
Polaron
Recombination, Genetic
Recombinant Transgenes
Palindromic Rheumatism
Homologous Recombination
Strand Invasion
Recombinants
Founder Mice, Transgenic
Transgenes

Related Papers

Molecular and Cellular Biology

Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism

Molecular and Cellular BiologyNovember 13, 2003
Lesley A CunninghamSusanna M Lewis
American Journal of Human Genetics

AT-rich palindromes mediate the constitutional t(11;22) translocation

American Journal of Human GeneticsNovember 30, 2000
L EdelmannB E Morrow
Paper Details
References
  • References32
  • Citations29
1234
  • References32
  • Citations29
123
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