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Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences

Proceedings of the National Academy of Sciences of the United States of America

Jul 17, 2001

Z Hong ZhouMaria Jasin

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Abstract

Genetic instability can be induced by unusual DNA structures and sequence repeats. We have previously demonstrated that a large palindrome in the mouse germ line derived from transgene integration is extremely unstable and undergoes stabilizing rearrangements at high frequency, often th...read more

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  • Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences

    Proceedings of the National Academy of Sciences of the United States of America

    Jul 17, 2001

    Z Hong ZhouMaria Jasin

    PMID: 11459971

    DOI: 10.1073/pnas.151008498

    Abstract

    Genetic instability can be induced by unusual DNA structures and sequence repeats. We have previously demonstrated that a large palindrome in the mouse germ line derived from transgene integration is extremely unstable and undergoes stabilizing rearrangements at high frequency, often th...read more

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    • References32
    • Citations28
    • References32
    • Citations28
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