Repeat liver retransplantation: rationale and outcomes

Clinical Transplantation
Riccardo MemeoDenis Castaing

Abstract

Liver retransplantation remains the only option for recurrent graft failure. The aim of our study is to identify predictive factors involved in patients and graft survival for patients undergoing repeat retransplantation (RRT). From January 1985 to December 2012, 2940 liver transplantations were performed in 2477 patients at Paul Brousse Hospital, Villejuif, France. All patients who underwent third, fourth, and fifth transplantation were included in the study and retrospectively analyzed. In the univariate analysis, the factors that were associated with 90-d patient post-operative survival were pre-operative vasopressors support, pre-operative extra hepatic sepsis, primary non-function (PNF) as indication of RRT, recipient's model of end stage liver disease (MELD), urgent RRT, creatinine value at RRT, and prothrombin ratio. The multivariate logistic regression confirmed the role of systemic septic status (OR = 12.8, p = 0.01) and vasopressor drug support (OR = 4.7, p = 0.05) as predictors of post-operative mortality. In the univariate analysis, the factors that were associated with patient 10 yr long-term survival (were vasopressor support, systemic septic patient, PNF as indication of RRT, RRT occurred between 1985 and 1999, r...Continue Reading

References

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Citations

Feb 23, 2018·Transplantation·Avesh J ThuluvathYulia Savva
Nov 30, 2018·Transplantation·Jacob D de BoerUNKNOWN Eurotransplant Liver and Intestine Advisory Committee (ELIAC)
Nov 27, 2019·Journal of Hepato-biliary-pancreatic Sciences·Kosei TakagiWojciech G Polak
Apr 13, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Pietro AddeoPhilippe Bachellier
Jul 21, 2017·Arquivos De Gastroenterologia·Emilio Elias AbdoTelesforo Bacchella
Jun 24, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Isabel M A BrüggenwirthUNKNOWN all the other contributing centers (www.eltr.org), the European Liver, Intestine Transplant Association (ELITA)

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