Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) - study protocol.

Systematic Reviews
Caroline A CrowtherPRECISE Study Group

Abstract

The aim of this individual participant data (IPD) meta-analysis is to assess whether the effects of repeat prenatal corticosteroid treatment given to women at risk of preterm birth to benefit their babies are modified in a clinically meaningful way by factors related to the women or the trial protocol. The Prenatal Repeat Corticosteroid International IPD Study Group: assessing the effects using the best level of Evidence (PRECISE) Group will conduct an IPD meta-analysis. The PRECISE International Collaborative Group was formed in 2010 and data collection commenced in 2011. Eleven trials with up to 5,000 women and 6,000 infants are eligible for the PRECISE IPD meta-analysis. The primary study outcomes for the infants will be serious neonatal outcome (defined by the PRECISE International IPD Study Group as one of death (foetal, neonatal or infant); severe respiratory disease; severe intraventricular haemorrhage (grade 3 and 4); chronic lung disease; necrotising enterocolitis; serious retinopathy of prematurity; and cystic periventricular leukomalacia); use of respiratory support (defined as mechanical ventilation or continuous positive airways pressure or other respiratory support); and birth weight (Z-scores). For the children, ...Continue Reading

References

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Citations

Feb 1, 2015·Paediatric Respiratory Reviews·Jose A Castro-RodriguezMonica P Sossa-Briceño
Dec 4, 2014·Journal of Developmental Origins of Health and Disease·C J D McKinlayJ E Harding
Sep 17, 2013·Orvosi hetilap·György Balla, Miklós Szabó
Mar 27, 2010·BMC Pregnancy and Childbirth·Fernando C BarrosUNKNOWN GAPPS Review Group
Jul 6, 2015·The Cochrane Database of Systematic Reviews·Caroline A CrowtherJane E Harding
Apr 30, 2016·Seminars in Perinatology·Ronald J WapnerUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Aug 31, 2021·Seminars in Perinatology·Stefan C KaneCaroline A Crowther
Sep 26, 2017·Seminars in Perinatology·Isabelle DehaeneUNKNOWN from the International Spontaneous Preterm birth Young Investigators group (I-SPY)

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PRECISE

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