Repeat Ultrasonography in the First Years after Therapy with Radioiodine Is Not Necessary in Most Patients with Papillary Thyroid Carcinoma when Postoperative Ultrasonography Is Negative: A Reduction of Costs and False-Positives

European Thyroid Journal
Pedro Weslley S RosárioMaria Regina Calsolari

Abstract

Periodic ultrasonography (US) examination is recommended in many patients with papillary thyroid carcinoma (PTC) after treatment with radioactive iodine (RAI), but recurrences are confirmed in few cases. This study determined whether the indication of US in the first years after treatment with RAI can be selective when postoperative US and posttherapy whole-body scanning (RxWBS) ruled out persistent neck disease. This was a prospective study. Two hundred and fifty-four patients with PTC (242 of intermediate risk) undergoing thyroidectomy and RAI, who had no apparent disease at the time of initial therapy (including negative postoperative US and RxWBS), were studied. The patients were followed up for 5 years after treatment with RAI by annual US. At the end of 5 years, 47 patients (18.5%) had at least one suspicious US, but neck recurrence was confirmed in only 4 patients (1.5% of all patients and 8.5% of those with suspicious US). The remaining cases were considered false-positives. US did not reveal disease in the first or second year after treatment with RAI in any patient. In the third, fourth, and fifth year after treatment with RAI, considering only patients with unstimulated Tg < 1 ng/mL in these assessments, US revealed ...Continue Reading

References

Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·A F CailleuxM Schlumberger
Feb 4, 2005·The Laryngoscope·Pedro Weslley Souza de RosárioAlvaro Luis Barroso
Sep 24, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Pedro Weslley Souza RosárioAlvaro Luís Barroso
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Cosimo DuranteUNKNOWN PTC Study Group
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pedro W RosárioMaria Regina Calsolari
Mar 25, 2014·European Journal of Endocrinology·Charlotte Lepoutre-LusseyLaurence Leenhardt
Apr 28, 2017·Thyroid : Official Journal of the American Thyroid Association·Hosu KimJae Hoon Chung
May 31, 2018·Thyroid : Official Journal of the American Thyroid Association·Suyeon ParkWon Gu Kim

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Citations

Aug 25, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaPierpaolo Trimboli
Sep 5, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Giullia Menuci Chianca LandenbergerErika Laurini de Souza Meyer

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