Repeat use of human recombinant bone morphogenetic protein-2 for second level lumbar arthrodesis

Spine
Kern SinghFrank M Phillips

Abstract

Prospective randomized controlled animal model. The purpose of this study is to determine whether the readministration of human recombinant bone morphogenetic protein-2 (rhBMP-2) induces an immune response and inhibits successful fusion in repeat posterolateral spinal surgery. Little research has been performed on the effectiveness or immunoreactivity of rhBMP-2 (Infuse, Medtronic, Memphis, TN) in the context of its reuse in posterolateral fusion spinal surgery at adjacent levels. A total of 34 New Zealand White rabbits underwent posterior intertransverse process fusion with the use of rhBMP-2 delivered on an absorbable collagen sponge (rhBMP-2/ACS). Two rabbits were killed early leaving 32 total rabbits. Serologic studies (Type I bovine collagen and rhBMP-2 antibodies) were obtained at 2-week intervals throughout the experiment. At 10 weeks, posteroanterior radiographs confirmed solid fusion masses in all rabbits. The 32 rabbits were randomly separated into 2 groups of 16, and each group underwent an adjacent level, bilateral intertransverse process fusion with either rhBMP-2/ACS or iliac crest. There was no statistical difference in fusion rates with repeat use of rhBMP-2 (n = 15/16, 94%) or iliac crest (n = 11/16, 69%) (P = ...Continue Reading

References

Oct 28, 2004·Archives of Pathology & Laboratory Medicine·Jasvir S KhuranaBenjamin A Alman
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven D GlassmanJohn R Dimar
Apr 7, 2007·Spine·Christoph J SiepeAndreas Korge
May 8, 2007·The Spine Journal : Official Journal of the North American Spine Society·Kern SinghS Tim Yoon

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Citations

Aug 27, 2013·The Spine Journal : Official Journal of the North American Spine Society·Martin F HoffmannDebra L Sietsema
Sep 3, 2013·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Adel Al-AsfourChrister Dahlin
Mar 20, 2012·The Spine Journal : Official Journal of the North American Spine Society·Rene Olivares-NavarreteBarbara D Boyan
Jun 25, 2016·Asian Spine Journal·Martin Franz HoffmannDebra Lynn Sietsema
Oct 22, 2019·Stem Cells Translational Medicine·Patricia García-GarcíaFlor María Pérez-Campo
Oct 16, 2020·Tissue Engineering and Regenerative Medicine·Hye-Ju SonJeong-Tae Koh
Aug 29, 2021·Pharmaceutics·Daniel García-SánchezFlor M Pérez-Campo

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