Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With Spectral-Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

American Journal of Ophthalmology
Ruti SellaNatalie A Afshari

Abstract

To evaluate the performance of the epithelial thickness mapping (ETM) of the iVue spectral-domain optical coherence tomography (SD-OCT) device (Optovue Inc, Fremont, California, USA) in normal and diseased cornea eyes. Reliability and validity analysis. Sixty eyes of 60 subjects were recruited for the study, which included normal subjects (n = 12) and patients with corneal diseases (12 patients each: dry eye syndrome [DES], contact lens wear, post-laser refractive surgery, and keratoconus). Three repeated scans were acquired on 3 iVue SD-OCTs with device-designated operators from consented subjects. Each subject was scanned on each device. Repeatability (based on random error of repeated scans) and reproducibility (including the random error and the instrument/operator variability) were assessed based on spatial zones derived from a 6-mm-diameter corneal ETM centered on the pupil and compared between the groups. Fifty-nine eyes qualified for final analysis. Seventy-one of 598 acquired scans (11.9%) were excluded owing to scan quality concerns. The percentage of disqualified scans was similar across normal (10.7%) and diseased eyes (12.1%). Of 527 qualified scans, 40 (7.6%) scans required manual edits of the segmentation lines. ...Continue Reading

Citations

Oct 3, 2019·Eye·Mohamed Abou ShoushaVictor L Perez
Dec 14, 2019·Eye & Contact Lens·William W BinottiPedram Hamrah
Nov 25, 2020·Indian Journal of Ophthalmology·Pooja KhamarKrati Gupta
Sep 25, 2020·Journal of Glaucoma·Ioannis HalkiadakisVasiliki Konstadinidou
Feb 12, 2021·American Journal of Ophthalmology·Koray Gumus, Stephen C Pflugfelder

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