Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis

European Radiology
Chunjie GuoTobias Granberg

Abstract

To compare the cross-sectional robustness of commonly used volumetric software and effects of lesion filling in multiple sclerosis (MS). Nine MS patients (six females; age 38±13 years, disease duration 7.3±5.2 years) were scanned twice with repositioning on three MRI scanners (Siemens Aera 1.5T, Avanto 1.5T, Trio 3.0T) the same day. Volumetric T1-weighted images were processed with FreeSurfer, FSL-SIENAX, SPM and SPM-CAT before and after 3D FLAIR lesion filling with LST. The whole-brain, grey matter (GM) and white matter (WM) volumes were calculated with and without normalisation to the intracranial volume or FSL-SIENAX scaling factor. Robustness was assessed using the coefficient of variation (CoV). Variability in volumetrics was lower within than between scanners (CoV 0.17-0.96% vs. 0.65-5.0%, p<0.001). All software provided similarly robust segmentations of the brain volume on the same scanner (CoV 0.17-0.28%, p=0.076). Normalisation improved inter-scanner reproducibility in FreeSurfer and SPM-based methods, but the FSL-SIENAX scaling factor did not improve robustness. Generally, SPM-based methods produced the most consistent volumetrics, while FreeSurfer was more robust for WM volumes on different scanners. FreeSurfer had m...Continue Reading

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Citations

Nov 21, 2019·Acta Neurologica Scandinavica·Ho-Joon LeeKang Min Park
Sep 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Won-Jin MoonSeol-Heui Han
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Aug 1, 2021·Multiple Sclerosis and Related Disorders·Hiroaki YokoteShuta Toru

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Software Mentioned

SIENAX
Structural Image Evaluation with Normalisation of Atrophy Cros...
BrainSuite
FSL FMRIB Software Library Statistical Parametric Mapping
LST
SPM12
Computational Anatomy Toolbox ( SPM - CAT )
FMRIB Software Library ( FSL )
SIENAX FMRIB Software Library Structural Image Evaluation with...
Statistical Parametric Mapping ( SPM )

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