Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

The British Journal of Ophthalmology
Danqi FangHaoyu Chen

Abstract

To investigate the repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography (SS-OCTA) metrics in healthy subjects. Thirty-three healthy normal subjects were enrolled. The macula was scanned four times by an SS-OCTA system using the 3 mm×3 mm mode. The superficial capillary map images were analysed using a MATLAB program. A series of parameters were measured: foveal avascular zone (FAZ) area, FAZ perimeter, FAZ circularity, parafoveal vessel density, fractal dimension and vessel diameter index (VDI). The repeatability of four scans was determined by intraclass correlation coefficient (ICC). Then the averaged results were analysed for intereye difference, correlation and agreement using paired t-test, Pearson's correlation coefficient (r), ICC and Bland-Altman plot. The repeatability assessment of the macular metrics exported high ICC values (ranged from 0.853 to 0.996). There is no statistically significant difference in the OCTA metrics between the two eyes. FAZ area (ICC=0.961, r=0.929) and FAZ perimeter (ICC=0.884, r=0.802) showed excellent binocular correlation. Fractal dimension (ICC=0.732, r=0.578) and VDI (ICC=0.707, r=0.547) showed moderate binocular corre...Continue Reading

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Citations

Oct 4, 2018·Translational Vision Science & Technology·Rachel E LindermanJoseph Carroll
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Dec 21, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N MihailovicM Alnawaiseh
May 21, 2019·Translational Vision Science & Technology·Konstantinos Pappelis, Nomdo M Jansonius
Nov 28, 2019·Translational Vision Science & Technology·Sonny CaplashH Nida Sen
May 23, 2020·Clinical Ophthalmology·Zerrin BayraktarMuharrem Karakaya
Jul 10, 2019·Current Eye Research·Hayati YilmazSumeyye Burcu Elpeze
Apr 14, 2021·Korean Journal of Ophthalmology : KJO·Yong Min LeeYoung Hoon Lee
Aug 28, 2021·Diagnostics·Ella F CourtieRichard J Blanch

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