PMID: 11312404Apr 20, 2001Paper

Repeatability of bronchial hyperresponsiveness to adenosine-5'-monophosphate (AMP) by a short dosimeter protocol

Thorax
G De MeerD S Postma

Abstract

To study bronchial responsiveness to adenosine 5'-monophosphate (AMP) in population surveys, repeatability of a rapid dosimetric method with quadrupling doses was evaluated. Volunteers with symptoms of airway respiratory allergy or asthma were invited for AMP challenges on two occasions. After each dose the fall in forced expiratory volume in one second (FEV(1)) compared with the post-saline value was determined. The cumulative doses of AMP needed to cause a fall in FEV(1) of 20% (PD(20)), 15% (PD(15)), and 10% (PD(10)) were calculated. Agreement was evaluated by means of kappa values. After excluding systematic differences in PD values on two occasions (t test), repeatability of a single estimation of the chosen PD values was calculated and expressed in doubling doses (DD). In 28 of 76 subjects a PD(20) was estimated on the two visits, in 29 subjects a PD(15) was estimated, and in 32 a PD(10) was obtained. Kappa values for a positive threshold were 0.89 for a cut off level for a 20% fall in FEV(1), 0.78 for a 15% fall in FEV(1), and 0.76 for a fall in FEV(1) of 10%. The PD values did not differ between the two visits and 95% repeatability of a single estimation was +/-1.7 DD for PD(20), +/-2.2 DD for PD(15), and +/-2.4 DD for ...Continue Reading

References

Jan 1, 1989·The Journal of Allergy and Clinical Immunology·Z DaxunS T Holgate
Feb 1, 1985·The Journal of Allergy and Clinical Immunology·M J Cushley, S T Holgate
Oct 1, 1994·Journal of Clinical Epidemiology·J K PeatD Combe
Mar 1, 1993·The American Review of Respiratory Disease·Y OosterhoffD S Postma
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·E J WeersinkG H Koëter

❮ Previous
Next ❯

Citations

Feb 1, 2006·International Archives of Allergy and Immunology·E J M KropJ S Van der Zee
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Gea De MeerDirkje S Postma
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Jul 31, 2013·Archivos de bronconeumología·Miguel Perpiñá TorderaUNKNOWN Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)
Jan 16, 2016·The Journal of Allergy and Clinical Immunology·Carlos CarpioFrancisco García-Río
Mar 18, 2011·The Journal of Allergy and Clinical Immunology·Olga E SavenijeMarjan Kerkhof
Feb 10, 2009·The Journal of Allergy and Clinical Immunology·Esmeralda J M KropJaring S van der Zee
Apr 13, 2007·Allergologia et immunopathologia·F Muñoz-López
Oct 27, 2018·The European Respiratory Journal·Teal S HallstrandUNKNOWN American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Lucia Spicuzza, Riccardo Polosa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Related Papers

American Journal of Respiratory and Critical Care Medicine
S D AndersonA R Clark
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Jim Parkerson, Dennis Ledford
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
S D Anderson, J D Brannan
© 2021 Meta ULC. All rights reserved