Abstract
To study bronchial responsiveness to adenosine 5'-monophosphate (AMP) in population surveys, repeatability of a rapid dosimetric method with quadrupling doses was evaluated. Volunteers with symptoms of airway respiratory allergy or asthma were invited for AMP challenges on two occasions. After each dose the fall in forced expiratory volume in one second (FEV(1)) compared with the post-saline value was determined. The cumulative doses of AMP needed to cause a fall in FEV(1) of 20% (PD(20)), 15% (PD(15)), and 10% (PD(10)) were calculated. Agreement was evaluated by means of kappa values. After excluding systematic differences in PD values on two occasions (t test), repeatability of a single estimation of the chosen PD values was calculated and expressed in doubling doses (DD). In 28 of 76 subjects a PD(20) was estimated on the two visits, in 29 subjects a PD(15) was estimated, and in 32 a PD(10) was obtained. Kappa values for a positive threshold were 0.89 for a cut off level for a 20% fall in FEV(1), 0.78 for a 15% fall in FEV(1), and 0.76 for a fall in FEV(1) of 10%. The PD values did not differ between the two visits and 95% repeatability of a single estimation was +/-1.7 DD for PD(20), +/-2.2 DD for PD(15), and +/-2.4 DD for ...Continue Reading
References
May 1, 1991·The Journal of Allergy and Clinical Immunology·R PolosaS T Holgate
Aug 1, 1991·The American Review of Respiratory Disease·J K PeatA J Woolcock
Feb 8, 1986·Lancet·J M Bland, D G Altman
Jan 1, 1989·The Journal of Allergy and Clinical Immunology·Z DaxunS T Holgate
Jan 1, 1989·Pediatric Pulmonology·W M van AalderenK Knol
Feb 1, 1985·The Journal of Allergy and Clinical Immunology·M J Cushley, S T Holgate
Jan 1, 1987·Thorax·S ChinnA O Papacosta
May 1, 1995·Thorax·A AvitalS Godfrey
Oct 1, 1994·Journal of Clinical Epidemiology·J K PeatD Combe
Mar 1, 1993·The American Review of Respiratory Disease·Y OosterhoffD S Postma
Jun 1, 1996·Thorax·E van VelzenR Aalbers
Mar 1, 1997·Thorax·E EgbagbeA E Tattersfield
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·E J WeersinkG H Koëter
Dec 24, 1997·Thorax·R Polosa, S T Holgate
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D A TaylorB J O'Connor
Citations
Jul 4, 2002·Thorax·R PolosaS T Holgate
Feb 1, 2006·International Archives of Allergy and Immunology·E J M KropJ S Van der Zee
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Gea De MeerDirkje S Postma
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Jul 31, 2013·Archivos de bronconeumología·Miguel Perpiñá TorderaUNKNOWN Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)
Mar 26, 2009·Chest·Graham L HallPeter J Franklin
Jan 16, 2016·The Journal of Allergy and Clinical Immunology·Carlos CarpioFrancisco García-Río
Mar 18, 2011·The Journal of Allergy and Clinical Immunology·Olga E SavenijeMarjan Kerkhof
Feb 10, 2009·The Journal of Allergy and Clinical Immunology·Esmeralda J M KropJaring S van der Zee
Apr 13, 2007·Allergologia et immunopathologia·F Muñoz-López
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G de MeerD Heederik
Dec 15, 2010·British Journal of Clinical Pharmacology·Lorna McKinlayBrian J Lipworth
Oct 27, 2018·The European Respiratory Journal·Teal S HallstrandUNKNOWN American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Lucia Spicuzza, Riccardo Polosa