Repeatability of long intracortical inhibition in healthy subjects

Clinical Neurophysiology Practice
Annika A de Goede, Michel J A M van Putten

Abstract

Transcranial magnetic stimulation (TMS) is widely used to assess cortical excitability. To detect changes in excitability with longitudinal studies, it is important to validate the repeatability of excitability measures within a subject between different sessions. Repeatability studies on long intracortical inhibition (LICI) are limited and reported agreement ranges from poor to good. This study aims to evaluate the repeatability of LICI in healthy subjects using paired pulse TMS. In addition, it investigates whether LICI repeatability differs for manual and robot-guided coil positioning. Thirty healthy subjects (10 males, mean age 28.4 ± 8.2 years) were studied twice, approximately one week apart. Both motor cortices were stimulated with 50 paired pulses (intensity 120% of resting motor threshold) at interstimulus intervals (ISIs): 50, 100, 150, 200, 250 and 300 ms. In twenty subjects a figure-of-eight coil was positioned and held in place manually during both sessions, while in ten subjects a robot-navigated arm was used. LICI repeatability was assessed using the intraclass correlation coefficient (ICC). For manual and robot-guided coil positioning we found a large variation in repeatability at the subject level and ISI level...Continue Reading

Citations

Jan 18, 2018·Brain : a Journal of Neurology·Prisca R BauerJosemir W Sander
May 23, 2019·Journal of Neurophysiology·Annika A de Goede, Michel J A M van Putten
Jun 27, 2018·Brain Topography·Annika A de GoedeMichel J A M van Putten
May 6, 2020·Brain Topography·Annika A de GoedeMichel J A M van Putten

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