Repeatability of lung density measurements with low-dose computed tomography in subjects with alpha-1-antitrypsin deficiency-associated emphysema

Investigative Radiology
J StolkB C Stoel

Abstract

Multislice computed tomography (MSCT) of the lungs provides a new opportunity for longitudinal assessment of lung densities because of shorter scan duration. The aim of the present study was to assess the intraindividual variation of lung densities measured by MSCT of patients with emphysema. Ten patients with emphysema participated in a study in which MSCT was obtained on two occasions, approximately 2 weeks apart. Scanning parameters were 140 kV, 20 mAs, 4 x 2.5-mm collimation, and effective slice thickness of 2.5 mm. Lung density was measured as the 15th percentile point and the relative area below -910 Hounsfield units (HU) by using Pulmo-LKEB software. The mean difference of the 15th percentile point was -1.29 +/- 3.2 HU, and that for the relative area below the -910-HU parameter was -1.02% +/- 3.09%. Intraclass coefficients of variation were 0.96 (0.86-0.99) and 0.94 (0.8-0.98), respectively (95% confidence interval). Lung density parameters of emphysema derived by MSCT provide an opportunity for analysis of the treatment effects of new drugs on the progression of emphysema.

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Citations

Aug 26, 2009·European Radiology·Massimo BellomiPatrick Maisonneuve
Oct 19, 2004·European Journal of Radiology·Mubeccel ArslanIsmail Salk
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Harvey O CoxsonDon D Sin
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Nov 1, 2009·Expert Opinion on Medical Diagnostics·Philippe A GrenierPierre-Yves Brillet
Aug 3, 2010·Respiratory Medicine·Elisabeth BernspångEeva Piitulainen
Jun 28, 2005·European Journal of Radiology·Nicola SverzellatiRocco Cobelli
Jul 10, 2013·Journal of Applied Clinical Medical Physics·Bruno HochheggerEdson Marchiori
Oct 16, 2004·Investigative Radiology·Berend C Stoel, Jan Stolk
Aug 26, 2009·Journal of Thoracic Imaging·Jonathan G Goldin
Aug 26, 2009·Journal of Thoracic Imaging·David A Lynch, John D Newell
Dec 2, 2017·The European Respiratory Journal·Marc MiravitllesRobert A Stockley
Jul 2, 2016·The European Respiratory Journal·William MacNee
Nov 24, 2005·Investigative Radiology·M Els BakkerBerend C Stoel
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Mar 2, 2019·Respiratory Research·Berend C StoelDavid G Parr
Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Andrew WestcottAlexei Ouriadov
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Jun 9, 2017·Scientific Reports·Benjamin A HoffCraig J Galbán
Apr 26, 2018·The Indian Journal of Radiology & Imaging·Ishan KumarS K Agarwal

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