Repeatable focal seizure suppression: a rat preparation to study consequences of seizure activity based on urethane anesthesia and reversible carotid artery occlusion

Journal of Neuroscience Methods
Takeshi SaitoMark Stewart

Abstract

Seizures can be associated with serious systemic complications (even death) due to autonomic nervous system or respiratory dysfunction. Clinical and laboratory studies examining the relationship between seizures and autonomic dysfunction have not resolved important questions, such as whether autonomic changes result primarily from muscle activation or from limbic cortical seizure activity, because correlational studies are limited by opportunities to observe seizures and study seizure spread. We describe a rat preparation that will greatly facilitate such studies. First, we show that systemic kainic acid in urethane anesthetized animals causes a period of status epilepticus as it does in ketamine/xylazine anesthetized or awake animals, but with a critical distinction: limbic cortical seizures occur without neocortical involvement. No paralytic agents are necessary to keep animals "safely" in a stereotaxic frame because there are not motor convulsions, yet animals continue to breathe on their own. Second, we describe the construction of a simple device to permit remote reversible unilateral or bilateral common carotid artery occlusion, and show that seizure activity in dorsal hippocampal regions can be unilaterally or bilaterall...Continue Reading

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Citations

Aug 16, 2012·The Journal of Physiological Sciences : JPS·Isaac NaggarMark Stewart
Aug 5, 2009·Autonomic Neuroscience : Basic & Clinical·Harumi HottaMark Stewart
Aug 12, 2009·Nature Reviews. Neurology·Rainer SurgesJosemir W Sander
Jun 17, 2020·Annals of Neurology·Yan SunAlexander Rotenberg
Mar 16, 2018·The Journal of Physiological Sciences : JPS·Mark Stewart
Oct 20, 2018·Epilepsy Research·Ryan B BuddePedro P Irazoqui

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