PMID: 9539265Apr 16, 1998Paper

Repeated administration of amphetamine induces sensitisation to its disruptive effect on prepulse inhibition in the rat

Psychopharmacology
J ZhangL Svensson

Abstract

Male Sprague-Dawley rats were repeatedly treated with amphetamine (AMP, 1 mg/kg, SC) at 3- day intervals for 15 days and tested for prepulse inhibition of acoustic startle after each treatment. This treatment regimen induced sensitisation in the animals as evidenced by a progressive increase in the disruptive effect of AMP on prepulse inhibition. Persistent changes in brain function was indicated, since an increase in disruptive effect was observed in sensitised animals also after a 22-day-long drug- and test-free period. The development of sensitisation was blocked by pretreatment with haloperidol (HPD, 0.1 mg/kg, SC), which suggests that sensitisation to the disruptive effect of AMP was dependent on dopamine (DA) D2 receptor activation. Furthermore, the development of sensitisation was blocked by adrenalectomy, which suggests that sensitisation was dependent also on circulating adrenal hormones. Increased DA-ergic activity has been implicated in the pathophysiology of schizophrenia and AMP-induced sensitisation to the neuronal functions that modulate prepulse inhibition may be an experimental model to investigate this hypothesis.

Citations

Jun 13, 2013·Behavioural Brain Research·Auxiliadora Mena, Luis G De la Casa
Mar 23, 2005·Biological Psychiatry·Catherine C TennShitij Kapur
May 28, 2014·Neuroscience Letters·Alanna GrantCecilia Flores
Jun 14, 2008·Neuroscience and Biobehavioral Reviews·Stephen M Siviy
Jan 21, 2006·Journal of Neuroscience Methods·Becky KinkeadArnold J Mandell
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Kerry E Culm, Ronald P Hammer

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