Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers

Translational Psychiatry
Rebecca L AshareHeath D Schmidt

Abstract

Tobacco smoking remains the leading cause of preventable death worldwide and current smoking cessation medications have limited efficacy. Thus, there is a clear need for translational research focused on identifying novel pharmacotherapies for nicotine addiction. Our previous studies demonstrated that acute administration of an acetylcholinesterase inhibitor (AChEI) attenuates nicotine taking and seeking in rats and suggest that AChEIs could be repurposed for smoking cessation. Here, we expand upon these findings with experiments designed to determine the effects of repeated AChEI administration on voluntary nicotine taking in rats as well as smoking behavior in human smokers. Rats were trained to self-administer intravenous infusions of nicotine (0.03 mg kg(-1) per 0.59 ml) on a fixed-ratio-5 schedule of reinforcement. Once rats maintained stable nicotine taking, galantamine or donepezil was administered before 10 consecutive daily nicotine self-administration sessions. Repeated administration of 5.0 mg kg(-1) galantamine and 3.0 mg kg(-1) donepezil attenuated nicotine self-administration in rats. These effects were reinforcer-specific and not due to adverse malaise-like effects of drug treatment as repeated galantamine and do...Continue Reading

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Citations

Dec 29, 2016·Psychopharmacology·Adriaan W Bruijnzeel
Feb 13, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·David E EvansRebecca L Ashare
Sep 25, 2017·ELife·Daniel Scott HimmelsteinSergio E Baranzini
Jun 27, 2020·International Journal of Molecular Sciences·Sylwester ŚlusarczykAdam Matkowski
Mar 25, 2020·Pharmacological Reviews·M J MoerkeJ L Wilkerson
Dec 19, 2017·Pharmacotherapy·Nieves Gómez-CoronadoSeetal Dodd
Sep 20, 2019·Therapeutic Advances in Respiratory Disease·Tatsuya NaganoYoshihiro Nishimura
Nov 22, 2020·Journal of Neurochemistry·Christine N Metz, Valentin A Pavlov
Sep 3, 2021·Journal of Smoking Cessation·Qutub Jamali
Mar 1, 2019·Molecular Neuropsychiatry·Heath D SchmidtNii A Addy

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Methods Mentioned

BETA
pharmacotherapies
pregnancy test

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